Inyongera 4 Zirwanya Gusaza mu kuzamura ubuzima bwa Mitochondrial: Ninde ukomeye?

Abahanga basanze uko tugenda dusaza, mitochondriya yacu igenda igabanuka buhoro buhoro kandi ikabyara ingufu nke. Ibi birashobora gutera indwara ziterwa nimyaka nkindwara zifata ubwonko, indwara z'umutima, nibindi byinshi.

Urolithin A.

Urolithin A ni metabolite isanzwe ifite ingaruka za antioxydeant na antiproliferative. Abahanga mu by'imirire bo muri kaminuza ya Nova y’Amajyepfo y’Amajyepfo muri Amerika bavumbuye ko gukoresha urolithine A mu rwego rwo gufata ibyokurya bishobora gutinza gusaza no gukumira indwara ziterwa n’imyaka.
Urolithin A (UA) ikorwa na bagiteri zo mu nda nyuma yo kurya polifenole iboneka mu biribwa nk'amakomamanga, strawberry, na walnuts. Kwiyongera kwa UA kumbeba zimaze imyaka ikora sirtuins kandi byongera NAD + ningufu za selile. Icy'ingenzi, UA yerekanwe gukuraho mitochondriya yangiritse ku mitsi y’abantu, bityo igatera imbaraga, kurwanya umunaniro, ndetse n’imikorere ya siporo. Kubwibyo, inyongera ya UA irashobora kongera igihe cyo kurwanya gusaza imitsi.
Urolithin A ntabwo iva mu ndyo yuzuye, ariko ibice nka acide ellagic na ellagitannine bikubiye mu mbuto, amakomamanga, inzabibu n'izindi mbuto bizatanga urolithine A nyuma yo guhindurwa na mikorobe yo mu nda.

Spermidine

Spermidine nuburyo busanzwe bwa polyamine yitabiriwe mumyaka yashize kubera ubushobozi bwayo bwo kongera igihe no kongera ubuzima. Kimwe na NAD + na CoQ10, spermidine ni molekile isanzwe ibaho igabanuka uko imyaka igenda ishira. Kimwe na UA, spermidine ikorwa na bagiteri zo munda kandi igatera mitofagy - kuvanaho mitochondriya itameze neza, yangiritse. Ubushakashatsi ku mbeba bwerekana ko inyongera ya spermidine ishobora kurinda indwara z'umutima no gusaza kw'imyororokere y'abagore. Byongeye kandi, spermidine yimirire (iboneka mubiribwa bitandukanye birimo soya nintete) byongera kwibuka mumbeba. Harakenewe ubushakashatsi bwinshi kugirango hamenyekane niba ibyo byagaragaye bishobora kwigana abantu.
Uburyo busanzwe bwo gusaza bugabanya kwibumbira mu miterere ya spermidine mu mubiri, nk'uko ubushakashatsi bwasohotse muri Scientific Reports bwakozwe n'abashakashatsi bo muri kaminuza y’ubuvuzi ya Kyoto Perefegitura mu Buyapani. Ariko, ibi bintu ntibyigeze bigaragara mu myaka ijana;
Spermidine irashobora guteza imbere autophagy.
Ibiribwa birimo spermidine nyinshi birimo: ibiryo by ingano, kelp, ibihumyo bya shiitake, imbuto, bracken, purslane, nibindi.

curcumin
Curcumin ningirakamaro ikora muri turmeric ifite anti-inflammatory na antioxidant.
Inzobere mu binyabuzima z’ubushakashatsi zaturutse mu Ishuri Rikuru ry’Ubumenyi rya Polonye zavumbuye ko curcumin ishobora kugabanya ibimenyetso byo gusaza no gutinza iterambere ry’indwara ziterwa n’imyaka aho ingirabuzimafatizo zigira uruhare rutaziguye, bityo bikongerera igihe.
Usibye turmeric, ibiryo birimo curcumin harimo: ginger, tungurusumu, igitunguru, urusenda rwirabura, sinapi na kariri.

NAD + inyongera
Ahari mitochondriya, hari NAD + (nicotinamide adenine dinucleotide), molekile ikenewe kugirango umusaruro mwinshi ugabanuke. NAD + isanzwe igabanuka uko imyaka igenda isa, bisa nkaho bihuye no kugabanuka kwimyaka kumikorere ya mito-iyambere. Iyi ni imwe mu mpamvu zatumye NAD + itera nka NR (Nicotinamide Ribose) yatejwe imbere kugirango igarure urwego rwa NAD +.
Ubushakashatsi bwerekana ko mugutezimbere NAD +, NR ishobora kongera ingufu za mito-iyambere kandi ikarinda guhangayikishwa nimyaka. Inyongera ya NAD + ibanziriza irashobora kunoza imikorere yimitsi, ubuzima bwubwonko, hamwe na metabolism mugihe ishobora kurwanya indwara zifata ubwonko. Byongeye kandi, bigabanya kwiyongera ibiro, kunoza insuline, no kugabanya urugero rwa lipide, nko kugabanya cholesterol ya LDL.