Kumenyekanisha Ibigezweho muri Alpha GPC Inyongera ya 2024

Choline Alfoscerate,bizwi kandi nka Alpha-GPC, ni ibintu byakuwe mu bimera bya lecithine, ariko ntabwo ari fosifolipide, ahubwo ni fosifolipide ikomoka ku bintu bya aside yitwa Lipophilique. Alpha-GPC nintungamubiri nyinshi ziboneka mu ngirangingo zose z’inyamabere. Kuberako ari hydrophilique cyane, ihita yinjira nyuma yubuyobozi bwo munwa. GPC ibanziriza acetylcholine (ACh) kandi ifite amasezerano akomeye mubikorwa bya choline.

GPC byoroshye kurenga inzitizi yubwonko bwamaraso kandi itanga isoko ya choline kuri biosynthesis ya ACh na phosphatidylcholine. Fosifolipide na acetylcholine, iyo bigerwaho kurwego rwiza, biteza imbere ubuzima bwubwenge, imitekerereze nubwonko. Mubyongeyeho, kwibanda kuri Alpha-GPC na Ach birashobora guteza imbere imikorere yumubiri no kunoza imikorere yumubiri. ACh igira uruhare mu kugabanya imitsi kandi niyo nyamukuru ya neurotransmitter igenga ibisubizo byumubiri kumyitozo ngororamubiri.

Kubera ko imitsi yose igenda ifitanye isano no kwikuramo, kandi kwikuramo bifitanye isano no kuboneka kwa selile ya ACh iboneka, kugabanya urugero rwa ACh bigabanya imikorere yimitsi. Ugereranije nibindi bibanziriza choline, Alpha-GPC itekanye kandi byongera urugero rwa choline mumaraso n'ubwonko. Ubushakashatsi bwinshi bwemeje inyungu zitandukanye za Alpha-GPC kandi bwerekana ko kuzuza umunwa bishobora kugira uruhare runini mu kuzamura imikorere y’imitsi, imikorere y’umubiri, no kunoza kwibuka.

Alpha-GPC

Kongera imbaraga z'ubwonko

Umubare munini w'uturemangingo tw'ubwonko mu bwonko, niko imbaraga zazo zikomeye, nikohereza vuba ibimenyetso by'imitsi, ndetse n'imbaraga zo gutunganya ubwonko. Alpha-GPC irashobora kunoza byimazeyo imikorere yubwonko yongerera imbaraga ingirabuzimafatizo nubushobozi bwo kwanduza ibimenyetso byimitsi. Mu rwego rwo kongera ubwonko bwa cholinergique, kwanduza ibimenyetso hagati ya selile nervice bishingiye ku kwanduza neurotransmitter, kandi acetylcholine nintumwa nyamukuru yimiti na neurotransmitter itanga ibitekerezo bikora kandi ikomeza guhuza ubwonko numubiri wose. Alpha-GPC irashobora kubora muri fosifate 3-glycerol na choline mu bwonko kandi ni yo itanga acetyloline nziza. Irashobora kongera kwibuka no kunoza imitekerereze iteza imbere synthesis no kurekura acetylcholine mubwonko. Mu rwego rwo kuzamura ituze n’amazi ya selile, Alpha-GPC irashobora guteza imbere synthesis ya fosifinositide, bityo bikazamura ituze n’amazi ya selile. Neuron ifite imiterere yuzuye irashobora kohereza amakuru neza no kunoza imitekerereze yumubiri. Koresha.

Rinda imitsi

Ibintu bikura byimyanya myakura, aribyo bintu bya neurotrophique, birashobora kugenga itandukanyirizo ryingirabuzimafatizo no guteza imbere imiterere mishya. Alpha-GPC irashobora guteza imbere gusohora ibintu bitandukanye bya neurotrophique kandi igakora inzira yerekana ibimenyetso bijyanye no kubaho kwakagari, bityo bikagira ingaruka kuri neuroprotective. Kunoza urwego rwubwenge. Muri icyo gihe, Alpha-GPC irashobora kandi guteza imbere imisemburo ikura kandi ikagumana ubuzima bwumubiri byongera imisemburo ikura yumubiri.

Antioxydants

Oxidation hamwe no gutwika nimpamvu nyamukuru zitera ingirabuzimafatizo ubwonko no gupfa. Alpha-GPC irashobora gukuramo radicals yubusa mumubiri, ikarwanya stress ya okiside, kandi irashobora kandi kugabanya umuriro nkibintu bya kirimbuzi NF-κB, ikibyimba cya niyose ya TNF-α, na interleukin IL-6. Kurekura ibintu birwanya ubwonko bwubwonko, bityo bigahindura cyane kugabanuka kwimikorere yubwenge no gukumira indwara niterambere ryindwara zifata ubwonko. Ingaruka zingirakamaro zashyigikiwe ningaruka zamavuriro.

Mu bushakashatsi bwakozwe "Ingaruka za Alpha-GPC ku bijyanye no kutagira kwibuka mu myaka", amasomo 4 yahawe umwanya, naho andi masomo 5 ahabwa Alpha-GPC (1200 mg / ku munsi), nyuma y’ubuyobozi bukomeza mu kanwa amezi 3, 16 electrode yakoreshejwe mu gufata amajwi yubwonko muminota 5 mugihe amasomo yari maso kandi aruhuka. Ibisubizo byerekanaga ko ugereranije na placebo, Alpha-GPC yashoboye kongera cyane igipimo cyubwonko bwihuta bwubwonko, mugihe gifite ubushake bwo kugabanya umuvuduko mwinshi. Ni ukuvuga, irashobora kongera imbaraga zubwonko bwabantu bageze mu za bukuru kandi bigatinda gusaza kwumubiri.

Tunganya amarangamutima

Dopamine irashobora gutuma abantu bumva bishimye, kandi serotonine na acide gamma-aminobutyric irashobora kugenga umubiri. Alpha-GPC irashobora guteza imbere irekurwa rya dopamine, kugenzura-kugenzura imvugo yabatwara dopamine, kunoza ubwonko bwa dopamine mu bwonko, no kongera urugero rwa serotonine muri striatum na cortex ibanza; irashobora kandi guteza imbere cyane γ- Kurekura aside aminobutyric igabanya kudasinzira, bityo ikagira ingaruka zayo zo kurwanya depression, kugabanya amaganya no guhagarika umutima.

Byongeye kandi, Alpha-GPC nayo isa nkaho ishobora kongera imbaraga zo kwinjiza fer itari heme mu biryo, bisa ningaruka za vitamine C ku kigereranyo cya 2: 1 hamwe nicyuma, bityo Alpha-GPC ifatwa nkaho, cyangwa kuri byibuze mutange umusanzu, kuzamura ibicuruzwa byinyama. Fenomenon yo kwinjiza fer ya nonheme. Byongeye kandi, kuzuza na Alpha-GPC birashobora kandi gufasha inzira yo gutwika amavuta no gushyigikira metabolism ya lipide. Ibi biterwa n'uruhare rwa choline nk'intungamubiri za lipofilique. Urwego rwiza rwintungamubiri rwemeza ko aside irike iboneka kuri selile mitochondria, ishobora guhindura ayo mavuta muri ATP cyangwa ingufu.

Amakuru agezweho

Alpha GPC imaze imyaka irenga 10 ikoreshwa. Kugeza ubu, Alpha GPC ni ibiryo bishya byibiribwa mu Buyapani kandi bikunze gukoreshwa mugutezimbere ibiryo bikora. Byongeye kandi, Amerika, Kanada, Ubusuwisi ndetse n’ibindi bihugu byemeje bikurikirana cyangwa byemerera Alpha GPC kongererwa ibiryo nyuma y’Ubuyapani. Muri Amerika, Alpha GPC igengwa nkibintu bisanzwe bizwi nkumutekano (GRAS). Muri Kanada, Alpha GPC yemerewe nkibicuruzwa byubuzima bisanzwe.

Porogaramu ku isoko n'ibicuruzwa bigenda

Urebye amakuru adahagije ku mutekano wa Alpha GPC ku mpinja, ku bagore batwite, no ku bagore bonsa, hashingiwe ku ihame ryo gukumira ingaruka, amatsinda yavuzwe haruguru ntagomba kuyarya, kandi ikirango n'amabwiriza bigomba kwerekana itsinda ridakwiye. Muri Amerika, Ubuyapani, Kanada no mu bindi bihugu, Alpha GPC yakoreshejwe cyane mu biribwa. Ibicuruzwa bifitanye isano bikubiyemo inyongeramusaruro, ibinyobwa, gummies nibindi byiciro, kandi buri gicuruzwa gifite imikorere isobanutse kandi gisabwa gukoreshwa.

Umubare hamwe nitsinda ryasabwe. Kurugero, muri Reta zunzubumwe zamerika, hariho inyongera zirenga 300 zokurya kuri Alpha GPC yonyine, hamwe ningaruka zisabwa zirimo kunoza imikorere yibikorwa no kumenya ubwenge, kunoza imikorere ya moteri, nibindi. Imiti ya buri munsi ni 300-1200 mg.
Imiterere yubu ikoranabuhanga ribyara umusaruro

Ubushakashatsi bwerekana ko synthesis ya chimique ari bumwe muburyo nyamukuru bwo gukora Alpha GPC. Ukoresheje aside polifosifike, chorine ya choline, R-3-chloro-1,2-propanediol, hydroxide ya sodium namazi nkibikoresho fatizo, nyuma ya kondegene na esterification reaction, irahinduka amabara, umwanda ukurwaho, kwibanda, gutunganywa no gukama. irashobora kuboneka kubindi bikorwa. Nyamara, synthesis gakondo ya chimique, hydrolysis ya chimique, alcoolisique chimique nubundi buryo byose bihura nibibazo nko guhumanya ibidukikije, igiciro kinini, hamwe nuburyo bwo gutegura bigoye.

Mu myaka yashize, gutegura Alpha GPC hakoreshejwe uburyo bwa bioenzymatique byitabiriwe cyane. Uburyo bwa enzymatique yo mu mazi, uburyo bwa enzymatique butari amazi, nibindi byagaragaye kimwekindi. Ugereranije nuburyo bwa chimique, gutegura Alpha GPC muburyo bwa bioenzymatic bifite imiterere yoroheje nuburyo bworoshye. , catalitike ikora neza kandi ibereye umusaruro munini wubucuruzi.

Suzhou Myland Pharm & Nutrition Inc ni uruganda rwanditswe na FDA rutanga ifu yuzuye kandi nziza-nziza ya Alpha GPC Ifu yinyongera.

Muri Pharm ya Suzhou Myland twiyemeje gutanga ibicuruzwa byiza cyane kubiciro byiza. Ifu yinyongera ya Alpha GPC irageragezwa cyane kugirango isukure nimbaraga, ikwemeza ko ubona inyongera nziza-nziza ushobora kwizera. Waba ushaka gushyigikira ubuzima bwimikorere ya selile, kuzamura sisitemu yumubiri cyangwa kuzamura ubuzima muri rusange, ifu yinyongera ya Alpha GPC niyo ihitamo neza.

Hamwe nuburambe bwimyaka 30 kandi itwarwa nubuhanga buhanitse hamwe nuburyo bunoze bwa R&D, Pharm ya Suzhou Myland Pharm yateje imbere ibicuruzwa bitandukanye byapiganiwe kandi ihinduka ubuzima bushya bwa siyanse yubuzima, synthèse progaramu na sosiyete ikora serivise.

Mubyongeyeho, Suzhou Myland Pharm nayo ikora FDA yemewe. Ibikoresho bya sosiyete R&D, ibikoresho byo kubyaza umusaruro, nibikoresho byisesengura nibigezweho kandi byinshi, kandi birashobora gukora imiti kuva kuri miligarama kugeza kuri toni mubipimo, kandi ikubahiriza ibipimo bya ISO 9001 nibisobanuro bya GMP.

Alpha GPC izwiho kuba hygroscopique, bivuze ko ikurura ubuhehere buturuka mu kirere gikikije. Kubera iyo mpamvu, inyongera zigomba kubikwa mubikoresho byumuyaga kandi ntibigomba guhura numwuka mugihe kinini.

Ibitekerezo byanyuma

Alpha GPC ikoreshwa mugutanga choline mubwonko hakurya ya barrière yamaraso. Nibibanziriza acetylcholine, neurotransmitter iteza imbere ubuzima bwubwenge. Alpha GPC inyongera zirashobora gukoreshwa kugirango bigirire akamaro ubuzima bwawe bwubwenge mugutezimbere kwibuka, kwiga, no kwibanda. Ubushakashatsi bwerekana kandi ko Alpha GPC ifasha kongera imbaraga zumubiri nimbaraga zimitsi.