Gushyira ahagaragara ibigezweho mu nyongeramusaruro za Alpha GPC muri 2024

Choline Alfoscerate,izwi kandi nka Alpha-GPC, ni ikintu gikomoka kuri lecithin y'ibimera, ariko si phospholipide, ahubwo ni phospholipide ikomoka kuri aside fatty acid ya Lipophilic. Alpha-GPC ni intungamubiri ifite imikorere myinshi iboneka mu turemangingo twose tw'inyamabere. Kubera ko ikunda amazi menshi, yinjizwa vuba nyuma yo kuyinywa. GPC ni ikintu cya mbere cya acetylcholine (ACh) kandi ifite icyizere gikomeye mu mikorere mibi ya choline.

GPC yambukiranya uruzitiro rw'amaraso n'ubwonko kandi igatanga isoko ya choline yo gukora ACh na phosphatidylcholine. Phospholipide na acetylcholine, iyo bigeze ku rwego rwiza, bitera ubuzima bwiza bwo mu mutwe, mu mutwe no mu bwonko. Byongeye kandi, gushyira hamwe Alpha-GPC na Ach bishobora guteza imbere imikorere y'umubiri no kunoza imikorere y'umubiri. ACh igira uruhare mu gutuma imitsi ikora neza kandi ni yo nyunganiramirire nyamukuru igenga uburyo umubiri ukora imyitozo ngororamubiri.

Kubera ko imitsi yose igenda ihura no guhagarara, kandi guhagarara bifitanye isano n'ubwinshi bwa ACh mu turemangingo, kongera urugero rwa ACh byongera imikorere y'imitsi. Ugereranyije n'ibindi bintu bisanzwe bibanziriza choline, Alpha-GPC yongera neza kandi mu buryo bwizewe urugero rwa choline mu maraso no mu bwonko. Ubushakashatsi bwinshi bwemeje ibyiza bitandukanye bya Alpha-GPC kandi bwerekana ko kongerera umubiri ibinyobwa bishobora kugira uruhare runini mu kongera imikorere y'imitsi, imikorere y'umubiri, no kunoza kwibuka.

Ingufu za Alpha-GPC

Ongera imbaraga z'ubwonko

Uko uturemangingo tw’imitsi tuba twinshi mu bwonko, ni ko imbaraga zatwo zirushaho gukomera, ni ko twohereza vuba ibimenyetso by’imitsi, kandi ni ko imbaraga z’ubwonko zo gutunganya zirushaho gukomera. Alpha-GPC ishobora kunoza imikorere y’ubwonko mu buryo bwuzuye binyuze mu kongera imbaraga z’uturemangingo tw’imitsi n’ubushobozi bwo kohereza ibimenyetso by’imitsi. Mu bijyanye no kongera uburyo bwo kohereza amakuru mu bwonko, kohereza amakuru hagati y’uturemangingo tw’imitsi bishingiye ku kohereza amakuru mu bwonko, kandi acetylcholine ni igikoresho cy’ingenzi gitanga ubutumwa n’uburyo bwo kohereza amakuru mu bwonko, kandi gikomeza guhuza ubwonko n’umubiri wose. Alpha-GPC ishobora guhindurwamo 3-glycerol phosphate na choline mu bwonko kandi niyo acetylcholine itangwa neza cyane. Ishobora kongera kwibuka no kunoza ibitekerezo binyuze mu guteza imbere imikorere n’irekurwa rya acetylcholine mu bwonko. Mu bijyanye no kongera imbaraga n’imikorere y’uturemangingo tw’imitsi, Alpha-GPC ishobora guteza imbere imikorere ya phosphoinositide, bityo ikongera imbaraga n’imikorere y’uturemangingo tw’imitsi. Uturemangingo dufite imiterere yuzuye dushobora kohereza amakuru neza no kunoza ubushobozi bw’umubiri bwo gutekereza. Spend.

Rinda imitsi

Ibintu bikura mu mitsi, ni ukuvuga ibintu bitera imitsi ku mitsi, bishobora kugenzura ihinduka ry’uturemangingo tw’umubiri no guteza imbere ishyirwaho ry’imitsi mishya. Alpha-GPC ishobora guteza imbere isohoka ry’ibintu bitandukanye bitera imitsi ku mitsi no gukora inzira z’ibimenyetso zijyanye no kubaho kw’uturemangingo, bityo ikagira ingaruka zo kurinda ubwonko. Yongera urwego rw’ubwonko mu mubiri. Muri icyo gihe, Alpha-GPC ishobora kandi guteza imbere isohoka ry’imisemburo itera imitsi no kubungabunga ubuzima bw’umubiri binyuze mu kongera urugero rw’imisemburo itera imitsi ku mubiri.

Antioxydants

Oxidation no kubyimba ni byo bintu by’ingenzi bituma uturemangingo tw’ubwonko dusaza kandi tugapfa. Alpha-GPC ishobora gukuraho uturemangingo tw’ubuntu mu mubiri, ikarwanya stress ya oxidative, kandi ikagabanya kubyimba nka nuclear factor NF-κB, tumor necrosis factor TNF-α, na interleukin IL-6. Irekurwa ry’ibintu birwanya kubyimba mu bwonko, bityo bigasubiza inyuma cyane kugabanuka k’imikorere y’ubwonko no gukumira indwara ziterwa n’ubwonko. Ingaruka zifatika zashimangiwe n’ingaruka z’ubuvuzi.

Mu bushakashatsi bwakozwe ku "Ingaruka za Alpha-GPC ku Bubi bwo Kwibuka Bufitanye isano n'Imyaka", abantu 4 bahawe placebo, abandi bantu 5 bahabwa Alpha-GPC (1200 mg / umunsi), nyuma yo guhabwa imiti mu gihe cy'amezi 3, electrode 16 zakoreshejwe mu kwandika imiraba y'ubwonko mu gihe cy'iminota 5 mu gihe abantu bari maso kandi baruhutse. Ibisubizo byagaragaje ko ugereranije na placebo, Alpha-GPC yashoboye kongera cyane igipimo cy'imiraba y'ubwonko yihuta cyane, mu gihe ifite akamenyero ko kugabanya inshuro zigenda buhoro. Ni ukuvuga ko ishobora kongera imbaraga z'ubwonko bw'abantu bari mu kigero cyo hagati no gutinda gusaza kw'umubiri.

Genda amarangamutima

Dopamine ishobora gutuma abantu bumva bishimye, kandi serotonin na aside gamma-aminobutyric bishobora kugenzura uko umubiri umerewe. Alpha-GPC ishobora guteza imbere irekurwa rya dopamine, kongera uburyo ibintu bitwara dopamine bikoreshwa, kunoza uburyo dopamine ikwirakwira mu bwonko, no kongera urugero rwa serotonin muri striatum na prefrontal cortex; ishobora kandi guteza imbere cyane γ- Irekurwa rya aside aminobutyric rigabanya ububabare bwo kubura ibitotsi, bityo rikagira ingaruka zo kurwanya kwiheba, kugabanya imihangayiko no gutuza amarangamutima.

Byongeye kandi, Alpha-GPC isa nkaho ishobora kongera uburyo icyuma kidakoresha heme cyinjizwa mu biribwa, kimwe n'ingaruka za vitamine C ku gipimo cya 2:1 hamwe n'icyuma, bityo Alpha-GPC ifatwa nk'aho, cyangwa byibuze igira uruhare mu kongera ibikomoka ku nyama. Ikintu cy'uburyo icyuma kidakoresha heme cyinjizwa mu nyama. Byongeye kandi, kongera Alpha-GPC bishobora no gufasha mu gutwika ibinure no gushyigikira imikorere y'ibinure. Ibi biterwa n'uruhare rwa choline nk'intungamubiri zitera lipophilic. Ingano nziza y'iyi ntungamubiri ituma aside irike iboneka kuri mitochondria y'uturemangingo, ishobora guhindura ibinure muri ATP cyangwa ingufu.

Amakuru mashya agenga amategeko

Alpha GPC imaze imyaka irenga 10 ikoreshwa. Kuri ubu, Alpha GPC ni ibiribwa bishya mu Buyapani kandi ikunze gukoreshwa mu guteza imbere ibiryo bikora neza. Byongeye kandi, Leta Zunze Ubumwe za Amerika, Kanada, Ubusuwisi n'ibindi bihugu byemeye cyangwa byemeye ko Alpha GPC yongerwa mu biribwa nyuma y'Ubuyapani. Muri Leta Zunze Ubumwe za Amerika, Alpha GPC igenzurwa nk'Ikiyobyabwenge Gisanzwe Cyemerwa nk'Ikinyabutabire (GRAS). Muri Kanada, Alpha GPC yemejwe nk'ibikomoka ku buzima karemano.

Ikoreshwa ry'isoko n'uburyo ibicuruzwa bihagaze

Bitewe n'uko amakuru adahagije ku mutekano wa Alpha GPC ku bana bato, abagore batwite, n'abagore bonsa, ashingiye ku ihame ryo kwirinda ibyago, amatsinda yavuzwe haruguru ntagomba kuyirya, kandi icyapa n'amabwiriza bigomba kugaragaza itsinda ritabikwiriye. Muri Leta Zunze Ubumwe za Amerika, mu Buyapani, muri Kanada no mu bindi bihugu, Alpha GPC yakoreshejwe cyane mu biribwa. Ibikoresho bifitanye isano bikubiyemo inyongeramusaruro, ibinyobwa, gummy n'ibindi byiciro, kandi buri gicuruzwa gifite akamaro kacyo kandi gisabwa gukoreshwa.

Ingano n'amatsinda yatanzwe. Urugero, muri Leta Zunze Ubumwe za Amerika, hari inyongeramusaruro zirenga 300 za Alpha GPC gusa, zifite ingaruka zirimo kunoza imikorere y'ubwonko n'imitekerereze, kunoza imikorere y'imitsi, n'ibindi. Igipimo cya buri munsi ni 300-1200 mg.
Aho ikoranabuhanga mu gukora rigeze ubu

Ubushakashatsi bwerekana ko gukora imiti mu buryo bwa shimi ari bumwe mu buryo bw'ingenzi bwa Alpha GPC. Hakoreshejwe aside polyphosphoric, choline chloride, R-3-chloro-1,2-propanediol, sodium hydroxide n'amazi nk'ibikoresho fatizo, nyuma yo gushonga no gusya, birahinduka ibara, umwanda ukurwaho, bigashyirwa hamwe, bigatunganywa kandi byumishwa. Ariko, gukora imiti mu buryo bwa gakondo, gukoresha imiti mu buryo bwa shimi, gukoresha imiti mu buryo bwa shimi, gukoresha imiti ikomoka ku shimi n'ubundi buryo bwose buhura n'ibibazo nko kwanduza ibidukikije, ibiciro bihenze, n'uburyo bugoye bwo kuyitegura.

Mu myaka ya vuba aha, gutegura Alpha GPC hakoreshejwe uburyo bwa bioenzymatic byarushijeho kwitabwaho cyane. Uburyo bwa Aqueous-phase enzyme, uburyo bwa Aqueous-phase enzymes, nibindi byagiye bigaragara kimwe ku kindi. Ugereranyije n'uburyo bwa chimique, gutegura Alpha GPC hakoreshejwe uburyo bwa bioenzymatic bifite uburyo bworoshye bwo gukora kandi byoroshye, bifite ubushobozi bwo gukora catalytic kandi bikwiranye n'umusaruro mu bucuruzi bunini.

Suzhou Myland Pharm & Nutrition Inc. ni uruganda rwemewe na FDA rutanga ifu y’inyongera ya Alpha GPC nziza kandi isukuye cyane.

Muri Suzhou Myland Pharm twiyemeje gutanga ibicuruzwa byiza cyane ku giciro cyiza. Ifu yacu ya Alpha GPC Supplement irageragezwa cyane kugira ngo imenyekane ko ari nziza kandi ifite imbaraga, bityo ukaba ubona inyunganizi nziza ushobora kwizera. Waba ushaka gufasha ubuzima bw'uturemangingo, kongera ubudahangarwa bw'umubiri wawe cyangwa kongera ubuzima bwiza muri rusange, ifu yacu ya Alpha GPC Supplement ni yo mahitamo meza.

Suzhou Myland Pharm ifite uburambe bw'imyaka 30 kandi iyobowe n'ikoranabuhanga rigezweho hamwe n'ingamba zo gukora ubushakashatsi n'iterambere zinoze cyane, yateje imbere ibicuruzwa bitandukanye kandi iba ikigo gishya gitanga serivisi z'inyongera ku buzima, gukora ibintu bitandukanye no gukora ibikoresho bitandukanye.

Byongeye kandi, Suzhou Myland Pharm ni uruganda rwanditswe na FDA. Imbuga z’ubushakashatsi n’iterambere by’iyi sosiyete, ibikoresho byayo byo gukora, n’ibikoresho byo gusesengura ni ibintu bigezweho kandi bifite imikorere myinshi, kandi bishobora gukora imiti kuva kuri miligarama kugeza kuri toni, kandi bikurikiza amahame ya ISO 9001 n’ibipimo bya GMP mu gukora.

Alpha GPC izwiho kuba ifite ubushobozi bwo gukurura ubushuhe buva mu kirere gikikije. Kubera iyo mpamvu, inyongeramusaruro zigomba kubikwa mu bikoresho bitagira umwuka kandi ntizigomba gushyirwa mu mwuka igihe kirekire.

Ibitekerezo bya nyuma

Alpha GPC ikoreshwa mu kugeza choline mu bwonko inyuze mu ruzitiro rw'amaraso n'ubwonko. Ni ikintu cya mbere cya acetylcholine, umusemburo w'ubwonko utuma ubwenge burushaho kugira ubuzima bwiza. Inyongeramusaruro za Alpha GPC zishobora gukoreshwa mu kugirira akamaro ubuzima bwawe bwo gutekereza binyuze mu kunoza kwibuka, kwiga no kwibanda ku bintu. Ubushakashatsi bwerekana kandi ko Alpha GPC ifasha kongera imbaraga z'umubiri n'imbaraga z'imitsi.