Ni ubuhe bwoko bw'uburyo bwo gukora intanga ngabo? Ni ibihe bintu by'ingenzi bigize intanga ngabo?

Spermidine ni polyamine y'ingenzi iboneka cyane mu binyabuzima kandi igira uruhare mu bikorwa bitandukanye bya biyoloji nko gukwirakwira kw'uturemangingo, gutandukanya utunyangingo no kugabanuka kw'uturemangingo. Hari ubwoko bwinshi bw'uburyo bwo gukora intanga: gukora imisemburo, gukora imisemburo no gukora imisemburo. Buri buryo bufite ibyiza n'ibibi byabwo byihariye hamwe n'uburyo bwo kubukoresha.

Biyosintesi ni yo nzira nyamukuru yo gukora intanga, ubusanzwe ikorwa binyuze mu ruhererekane rw'ibikorwa bya enzymatic mu turemangingo. Biyosintesi y'intanga ahanini ishingira ku mikorere ya aside amine, cyane cyane lysine na arginine. Ubwa mbere, lysine ihindurwamo aside aminebutyric (Putrescine) na lysine decarboxylase, hanyuma aside aminebutyric ihuzwa na aside amine munsi y'igikorwa cya spermine synthase kugira ngo ikore intanga. Byongeye kandi, gukora intanga binakubiyemo imikorere ya polyamines, nka putrescine (Cadaverine) na spermine (Spermine). Impinduka mu bwinshi bw'izi polyamines mu turemangingo zigira ingaruka ku gukora intanga.

Gutunganya intanga ni uburyo bukunze gukoreshwa mu gukora intanga muri laboratwari. Ibinyabutabire byoroheje bisanzwe bihindurwamo intanga binyuze mu gukora intanga. Inzira zisanzwe zo gukora intanga zitangirira kuri aside amine hanyuma zikabona intanga binyuze mu buryo butandukanye bwo gukora intanga, kuzigabanya no kuzishyira mu mubiri. Akamaro k'ubu buryo ni uko bushobora gukorwa mu bihe bigenzurwa, ubuziranenge bw'ibicuruzwa ni bwinshi, kandi bukwiriye ubushakashatsi buto muri laboratwari. Ariko, gukora intanga busanzwe bisaba gukoresha ibintu bisukura intanga na katalisiti, bishobora kugira ingaruka ku bidukikije.

Gutunganya enzyme ni uburyo bushya bwo gukora enzyme bwakozwe mu myaka ya vuba aha, bukoresha uburyo bwihariye bwo gukora enzymes mu gukora spermine. Ibyiza by'ubu buryo ni uburyo bworoshye bwo gukora spermine, guhitamo neza, no kubungabunga ibidukikije. Binyuze mu ikoranabuhanga rya genetiki, spermine synthase ikora neza ishobora kuboneka, bityo ikarushaho kunoza imikorere yayo. Gutunganya enzyme bifite amahirwe menshi yo gukoreshwa mu nganda, cyane cyane mu bijyanye n'ubuvuzi bw'ibinyabuzima n'inyongeramusaruro z'ibiribwa.

Ibice by'ingenzi bigize intanga ni polyamine, harimo intanga, putrescine na triamine. Imiterere ya molekile y'intanga igizwe n'amatsinda menshi ya amino na imino, kandi ifite imikorere ikomeye ya biyoloji. Ubushakashatsi bwagaragaje ko intanga igira uruhare runini mu kwiyongera kw'uturemangingo, kurwanya oxidation, no kurwanya gusaza. Mu myaka ya vuba aha, ubushakashatsi bwinshi bwagaragaje ko intanga ifitanye isano rya hafi no kubaho no gukura kw'indwara zitandukanye, nka kanseri, indwara z'umutima n'imitsi, n'indwara zo kwangirika kw'ubwonko. Kubwibyo, gukora no gukoresha intanga byakuruye ibitekerezo byinshi.

Mu bikorwa bifatika, intanga zishobora gukoreshwa atari nk'ikintu gikoreshwa mu bushakashatsi bw'ibinyabuzima gusa, ahubwo no nk'inyongera ku biribwa n'ibikomoka ku buzima. Uko abantu barushaho kwita ku buzima, ni ko isoko ry'intanga rigenda ryiyongera buhoro buhoro. Mu kunoza uburyo bwo gukora intanga, umusaruro wazo n'ubuziranenge bwazo bishobora kwiyongera, kandi ikiguzi cyo kuzikora gishobora kugabanuka, bityo bigateza imbere ikoreshwa ryazo mu nzego zitandukanye.

Muri rusange, uburyo bwo gukora intanga ngabo burimo ahanini gukora imisemburo, gukora imisemburo ya chimique no gukora imisemburo ya enzyme. Buri buryo bufite ibyiza byabwo byihariye n'ibintu bifatika. Ubushakashatsi bw'ejo hazaza bushobora kwibanda ku kunoza imikorere myiza y'intanga ngabo, kugabanya ingaruka ku bidukikije no kwagura ahantu hakoreshwa. Hamwe n'iterambere rihoraho rya siyansi n'ikoranabuhanga, gukora intanga ngabo no kuzikoresha bizazana amahirwe mashya yo gutera imbere.