Niki ukeneye kumenya kuri nicotinamide adenine dinucleotide (NAD +)?

NAD + nayo yitwa coenzyme, kandi izina ryayo ryuzuye ni nicotinamide adenine dinucleotide. Ni coenzyme yingenzi muri cycle ya tricarboxylic. Itera metabolisme yisukari, ibinure, na aside amine, igira uruhare muguhuza ingufu, kandi ikagira uruhare mubihumbi n'ibihumbi muri buri selile. Umubare munini wamakuru yubushakashatsi yerekana ko NAD + igira uruhare runini mubikorwa bitandukanye byibanze byumubiri mubinyabuzima, bityo ikagira uruhare mubikorwa byingenzi bya selile nka metabolism yingufu, gusana ADN, guhindura genetike, gutwika, injyana ya biologiya, no kurwanya imihangayiko.

Nk’ubushakashatsi bufite akamaro, urwego rwa NAD + mu mubiri wumuntu ruzagabanuka uko imyaka igenda ishira. Kugabanuka kurwego rwa NAD + bishobora gutera kugabanuka kwimitsi, kubura iyerekwa, umubyibuho ukabije, imikorere yumutima kugabanuka nibindi bikorwa bigabanuka. Kubwibyo, uburyo bwo kongera urwego rwa NAD + mumubiri wumuntu byahoze ari ikibazo. Ingingo yubushakashatsi bushyushye mumuryango wibinyabuzima.

Kuki NAD + igabanuka?

Kuberako, uko dusaza, kwangirika kwa ADN biriyongera. Mugihe cyo gusana ADN, ibyifuzo bya PARP1 biriyongera, ibikorwa bya SIRT ni bike, ikoreshwa rya NAD + ryiyongera, kandi umubare wa NAD + uragabanuka bisanzwe.

Niba twuzuza bihagijeNAD +, tuzabona ko imirimo myinshi yumubiri itangira kugarura ubusore.

Ingirabuzimafatizo zirimo NAD +. Turacyakeneye kubyuzuza?

Umubiri wacu ugizwe na selile zigera kuri tiriyoni 37. Ingirabuzimafatizo zigomba kuzuza "akazi" cyangwa reaction ya selile kugirango ikomeze. Buri selile 37 trillion yawe biterwa na NAD + kugirango ikore akazi kayo.

Uko abatuye isi basaza, indwara ziterwa no gusaza nk'indwara ya Alzheimer, indwara z'umutima, ibibazo bihuriweho, ibitotsi n'ibibazo by'umutima n'imitsi byahindutse indwara zikomeye zibangamira ubuzima bw'abantu.

Kubwibyo, kuva NAD yavumburwa nabahanga bo muri Amerika, NAD yinjiye mubuzima bwabantu, kandi NAD + ninyongera zayo zerekanye amahirwe menshi yo gukoreshwa mukurinda indwara ziterwa no gusaza.

① NAD + ikora nka coenzyme muri mitochondria kugirango iteze imbere metabolike. NAD + igira uruhare runini mubikorwa byo guhinduranya nka glycolysis, TCA cycle (bita Krebs cycle cyangwa citric acide cycle) hamwe numuyoboro wa transport wa electron. Nuburyo selile zibona ingufu. Gusaza hamwe nimirire ya calorie nyinshi bigabanya urugero rwa NAD + mumubiri.

Ubushakashatsi bwerekanye ko mu mbeba zishaje, gufata inyongera za NAD + byagabanije imirire- cyangwa imyaka ijyanye no kongera ibiro no kongera ubushobozi bwimyitozo ngororamubiri. Byongeye kandi, ubushakashatsi bwanahinduye ingaruka za diyabete ku mbeba z’abagore, byerekana ingamba nshya zo kurwanya indwara ziterwa n’umubyibuho ukabije.

NAD + ihuza imisemburo kandi ikohereza electron hagati ya molekile. Electron ni ishingiro ryingufu za selile. NAD + ikora kuri selile nko kwishyuza bateri. Iyo electron zimaze gukoreshwa, bateri irapfa. Muri selile, NAD + irashobora guteza imbere ihererekanyabubasha rya elegitoronike kandi igatanga ingufu muri selile. Muri ubu buryo, NAD + irashobora kugabanya cyangwa kongera ibikorwa bya enzyme, iteza imbere imvugo ya gene na signal ya selile.

② NAD + ifasha kugenzura ibyangiritse kuri ADN

Mugihe ibinyabuzima bisaza, ibintu bibi bidukikije nkimirasire, umwanda, no kwigana ADN bidakwiye birashobora kwangiza ADN. Iyi ni imwe mu nyigisho zo gusaza. Ingirabuzimafatizo hafi ya zose zirimo "imashini ya molekile" kugirango isane ibyangiritse.

Uku gusana bisaba NAD + ningufu, bityo kwangirika kwa ADN birenze urugero bitwara umutungo wa selile. Imikorere ya PARP, proteine ​​ikomeye yo gusana ADN, nayo biterwa na NAD +. Gusaza bisanzwe bitera ADN kwangirika mu mubiri, RARP iriyongera, bityo NAD + igabanuka. ADN ya Mitochondrial yangiritse ku ntambwe iyo ari yo yose izongera ubukana.

③ NAD +bigira ingaruka kumikorere yo kuramba gene Sirtuins kandi ikabuza gusaza

Indwara ya sirtuins irambye yavumbuwe, izwi kandi ku izina rya "abarinzi ba gen", igira uruhare runini mu kubungabunga ubuzima bw'utugari. Sirtuins ni umuryango wimisemburo igira uruhare mugukemura ibibazo bya selile no gusana ibyangiritse. Bagira uruhare kandi mu gusohora insuline, gusaza, hamwe n’ubuzima bujyanye n’ubusaza nkindwara zifata ubwonko na diyabete.

NAD + ni lisansi ifasha sirtuins gukomeza uburinganire bwa genome no guteza imbere gusana ADN. Nkuko imodoka idashobora kubaho idafite lisansi, Sirtuins isaba NAD + kugirango ikore. Ibisubizo bivuye mu bushakashatsi bw’inyamaswa byerekana ko kongera urwego rwa NAD + mu mubiri bikora poroteyine za sirtuin kandi bikongerera igihe cyo kubaho mu musemburo n'imbeba.

Function Imikorere y'umutima

Kuzamura urwego rwa NAD + birinda umutima kandi bigateza imbere imikorere yumutima. Umuvuduko ukabije wamaraso urashobora gutera umutima munini hamwe nimiyoboro ifunze, bishobora gutera ubwonko. Nyuma yo kuzuza urwego rwa NAD + mumutima ukoresheje inyongera ya NAD +, ibyangiritse kumutima biterwa na reperfusion birabujijwe. Ubundi bushakashatsi bwerekanye ko inyongera za NAD + nazo zirinda imbeba kwaguka k'umutima bidasanzwe.

⑤ Neurodegeneration

Imbeba zifite uburwayi bwa Alzheimer, kongera urwego rwa NAD + byongera imikorere yubwenge mugabanya iyubaka rya poroteyine zibangamira itumanaho ryubwonko. Kuzamura urwego rwa NAD + birinda kandi ingirabuzimafatizo zo mu bwonko gupfa igihe nta maraso ahagije yinjira mu bwonko. NAD + isa nkaho ifite amasezerano mashya mukurinda neurodegeneration no kunoza kwibuka.

System Sisitemu yo kwirinda

Mugihe tugenda dusaza, sisitemu z'umubiri ziragabanuka kandi dushobora kwibasirwa n'indwara. Ubushakashatsi buherutse gukorwa bwerekana ko urwego rwa NAD + rufite uruhare runini mugutunganya ubudahangarwa bw'umubiri no gutwika no kubaho kwa selile mugihe cyo gusaza. Ubushakashatsi bwerekana ubushobozi bwo kuvura NAD + bwo kudakora neza.

Isano iri hagati yuruhare rwa NAD + no gusaza

Coenzymes igira uruhare mu guhinduranya ibintu by'ingenzi nk'isukari, ibinure, na poroteyine mu mubiri w'umuntu, kandi bigira uruhare runini mu kugenga umubiri n'ingufu z'umubiri no gukomeza imikorere isanzwe ya physiologiya. NAD ni coenzyme yingenzi cyane mumubiri wumuntu, nanone yitwa coenzyme I. Ifite uruhare mubihumbi n'ibihumbi bya redox enzymatique reaction mumubiri wumuntu. Nibintu byingirakamaro kuri metabolism ya buri selile. Ifite imirimo myinshi, imirimo nyamukuru ni:

1. Guteza imbere umusaruro wa bioenergy

NAD + itanga ATP binyuze mu guhumeka kwa selile, ikuzuza mu buryo butaziguye ingufu za selile no kuzamura imikorere ya selile;

2. Gusana ingirabuzima fatizo

NAD + niyo substrate yonyine ya ADN yo gusana enzyme PARP. Ubu bwoko bwa enzyme bugira uruhare mu gusana ADN, bufasha gusana ADN na selile byangiritse, bigabanya amahirwe yo guhinduka kwa selile, kandi bikarinda kanseri;

3. Koresha poroteyine zose zo kuramba

NAD + irashobora gukora poroteyine 7 zose zo kuramba, bityo NAD + igira ingaruka zikomeye mukurwanya gusaza no kongera igihe cyo kubaho;

4. Komeza imbaraga z'umubiri

NAD + ishimangira ubudahangarwa bw'umubiri kandi itezimbere ubudahangarwa bw'umubiri muguhitamo guhindura ubuzima n'imikorere ya selile T igenga.

5. Guteza imbere imikurire yimisatsi

Impamvu nyamukuru itera umusatsi ni ugutakaza umusatsi ubuzima bwimitsi ya nyina, kandi gutakaza imbaraga za mama ya selile ni ukubera ko urwego rwa NAD + mumubiri wumuntu rugabanuka. Utugingo ngengabuzima twimisatsi ntabwo dufite ATP ihagije kugirango ikore synthesis proteine ​​yimisatsi, bityo itakaza imbaraga kandi iganisha kumisatsi.

6. Gucunga ibiro, guteza imbere metabolism

Muri 2017, Porofeseri David Sinclair wo mu Ishuri Rikuru ry’Ubuvuzi rya Harvard hamwe n’itsinda ryo mu Ishuri Rikuru ry’Ubuvuzi rya Ositaraliya bakoze ubushakashatsi bugereranya ku mbeba z’abagore bafite umubyibuho ukabije bakora imyitozo ku byumweru 9 kandi bafata NMN buri munsi mu minsi 18. Ubushakashatsi bwerekanye ko NMN igira ingaruka ku mavuta yo mu mwijima. Kandi ingaruka ya synthesis biragaragara ko iruta iyo myitozo.

Ikigaragara ni uko gusaza biherekejwe no kugabanuka gahoro gahoro mubice na selile NAD + murwego rwibinyabuzima bitandukanye byicyitegererezo, harimo imbeba nabantu. Kugabanuka kurwego rwa NAD + bifitanye isano nindwara nyinshi zijyanye no gusaza, harimo kugabanuka kwubwenge, kanseri, indwara ya metabolike, sarcopenia, nintege nke.

Nigute nshobora kuzuza NAD + buri munsi?

Nta soko ridashira rya NAD + mumubiri. Ibirimo nibikorwa bya NAD + mumubiri wumuntu bizagabanuka uko imyaka igenda ishira, kandi bizagabanuka vuba nyuma yimyaka 30, bivamo gusaza kwingirabuzimafatizo, apoptose no gutakaza ubushobozi bushya. .

Byongeye kandi, kugabanuka kwa NAD + bizanatera urukurikirane rwibibazo byubuzima, niba rero NAD + idashobora kuzuzwa mugihe, ingaruka zirashobora gutekerezwa.

1.Inyongera ku biryo

Ibiribwa nka keleti, broccoli, avoka, igikoma, ibihumyo, na edamame birimo NAD + ibanziriza, ishobora guhinduka NAD * ikora mumubiri nyuma yo kuyakira.

2.Gabanya indyo na karori

Kugabanya kalorike ntarengwa irashobora gukora inzira-yumvikanisha inzira muri selile kandi ikazamura mu buryo butaziguye urwego rwa NAD *. Ariko menya neza ko urya indyo yuzuye kugirango uhuze umubiri wawe

3. Komeza gukora no gukora siporo

Imyitozo ngororangingo iringaniye nko kwiruka no koga irashobora kongera urwego rudasanzwe rwa NAD +, rufasha kongera umwuka wa ogisijeni mu mubiri no kuzamura imbaraga za metabolism.

4. Kurikiza ingeso nziza zo gusinzira

Mugihe cyo gusinzira, umubiri wumuntu ukora ibintu byinshi byingenzi byo guhinduranya no gusana, harimo na synthesis ya NAD *. Gusinzira bihagije bifasha kugumana urwego rusanzwe rwa NAD

5. Ongeraho NAD + ibintu byabanjirije

Acide Nikotinike (NA) na nicotinamide (NAM) byombi bibanziriza NAD +. Birashobora guhuzwa no guhinduka muri NAD mumubiri wumuntu, bityo bikongera ibiyirimo. Ariko, kubera imipaka yinzira ya synthesis hamwe na enzymes zigabanya igipimo, bioavailability irahari. .

6 Ongeraho mu buryo butaziguye NAD +

Exogenous inyongera ya NAD + irashobora kugarura byihuse urwego rwa NAD + mumubiri, bigatuma ingingo zingenzi nkumutima nubwonko zibona inyongera NAD + nziza.

Suzhou Myland Pharm & Nutrition Inc ni uruganda rwanditswe na FDA rutanga ifu yuzuye kandi yuzuye-NAD + ifu yinyongera.

Muri Pharm ya Suzhou Myland twiyemeje gutanga ibicuruzwa byiza cyane kubiciro byiza. Ifu yinyongera ya NAD + irageragezwa cyane kugirango isukure nimbaraga, ikwemeza ko ubona inyongera-nziza nziza ushobora kwizera. Waba ushaka gushyigikira ubuzima bwimikorere, kuzamura sisitemu yumubiri cyangwa kuzamura ubuzima muri rusange, ifu yinyongera ya NAD + niyo ihitamo neza.

Hamwe nuburambe bwimyaka 30 kandi itwarwa nubuhanga buhanitse hamwe nuburyo bunoze bwa R&D, Pharm ya Suzhou Myland Pharm yateje imbere ibicuruzwa bitandukanye byapiganiwe kandi ihinduka ubuzima bushya bwa siyanse yubuzima, synthèse progaramu na sosiyete ikora serivise.

Mubyongeyeho, Suzhou Myland Pharm nayo ikora FDA yemewe. Ibikoresho bya sosiyete R&D, ibikoresho byo kubyaza umusaruro, nibikoresho byisesengura nibigezweho kandi byinshi, kandi birashobora gukora imiti kuva kuri miligarama kugeza kuri toni mubipimo, kandi ikubahiriza ibipimo bya ISO 9001 nibisobanuro bya GMP.