Ni iki ukeneye kumenya kuri nicotinamide adenine dinucleotide (NAD+)?

NAD+ yitwa kandi coenzyme, kandi izina ryayo ryuzuye ni nicotinamide adenine dinucleotide. Ni coenzyme y'ingenzi mu mikorere ya aside tricarboxylic. Itera imbere mu mikorere ya isukari, ibinure, na aside amine, igira uruhare mu gukora ingufu, kandi igira uruhare mu bikorwa byinshi by'ibanze muri buri turemangingo. Amakuru menshi y'ubushakashatsi agaragaza ko NAD+ igira uruhare runini mu bikorwa bitandukanye by'ibanze by'umubiri mu mubiri, bityo ikagira uruhare mu mikorere y'ingenzi y'uturemangingo nko gukora ingufu, gusana ADN, guhindura imiterere y'uturemangingo, kubyimba, imivuduko y'ibinyabuzima, no kurwanya stress.

Dukurikije ubushakashatsi bufatika, urugero rwa NAD+ mu mubiri w'umuntu ruzagabanuka uko imyaka igenda ishira. Kugabanuka k'urugero rwa NAD+ bishobora gutera kugabanuka k'imitsi, kubura amaso, umubyibuho ukabije, kugabanuka k'imikorere y'umutima n'ibindi bibazo by'imikorere. Kubwibyo, uburyo bwo kongera urugero rwa NAD+ mu mubiri w'umuntu bwagiye buhora ari ikibazo. Insanganyamatsiko y'ubushakashatsi ishyushye mu muryango w'abaganga b'indwara z'imiti.

Kuki NAD+ igabanuka?

Kubera ko, uko tugenda dusaza, kwangirika kwa ADN kuriyongera. Mu gihe cyo gusana ADN, icyifuzo cya PARP1 kiriyongera, imikorere ya SIRT iba mike, ikoreshwa rya NAD+ ririyongera, kandi ingano ya NAD+ iragabanuka mu buryo busanzwe.

Niba twongereye bihagijeNAD+, tuzasanga imikorere myinshi y'umubiri itangira kugarura ubuto.

Utunyangingo tuba tugizwe na NAD+. Ese turacyakeneye kongeramo?

Umubiri wacu ugizwe n'uturemangingo tugera kuri tiriyari 37. Uturemangingo tugomba kurangiza "ibikorwa" byinshi cyangwa ibikorwa by'uturemangingo kugira ngo twigumane. Buri turemangingo twawe turi tiriyari 37 dushingiye kuri NAD+ kugira ngo dukore akazi kayo gahoraho.

Uko abatuye isi bagenda bakura, indwara ziterwa no gusaza nka Alzheimer, indwara z'umutima, ibibazo by'ingingo, ibitotsi n'indwara z'umutima n'imitsi byabaye indwara zikomeye zibangamira ubuzima bw'abantu.

Kubera iyo mpamvu, kuva aho NAD ivumbuwe n'abahanga mu bya siyansi b'Abanyamerika, NAD yinjiye mu buzima bw'abantu, kandi NAD+ n'inyongera zayo byagaragaje amahirwe menshi yo kuyikoresha mu gukumira indwara ziterwa no gusaza.

① NAD+ ikora nka coenzyme muri mitochondria kugira ngo irusheho kuringaniza imikorere y’umubiri. NAD+ igira uruhare runini mu mikorere y’imikorere y’umubiri nka glycolysis, TCA cycle (izwi nka Krebs cycle cyangwa citric aside cycle) ndetse n’uruhererekane rw’amashanyarazi. Ni uburyo uturemangingo tubona ingufu. Gusaza no kurya indyo irimo karori nyinshi bigabanya urugero rwa NAD+ mu mubiri.

Ubushakashatsi bwagaragaje ko mu mbeba zishaje, gufata inyongeramusaruro za NAD+ bigabanya ibiro bitewe n’indyo cyangwa gusaza ndetse binatuma ubushobozi bwo gukora imyitozo ngororamubiri burushaho kwiyongera. Byongeye kandi, ubushakashatsi bwahinduye ingaruka za diyabete mu mbeba z’ingore, bwerekana ingamba nshya zo kurwanya indwara z’imikorere mibi y’umubiri nk’umubyibuho ukabije.

NAD+ ifatana na enzymes kandi ikohereza electrons hagati ya molecules. Electrons ni zo shingiro ry'ingufu za selile. NAD+ ikora ku turemangingo nko kongera gusharija bateri. Iyo electrons zirangiye, bateri irapfa. Mu turemangingo, NAD+ ishobora guteza imbere kohereza electrons no gutanga ingufu ku turemangingo. Muri ubu buryo, NAD+ ishobora kugabanya cyangwa kongera imikorere ya enzymes, igateza imbere imikorere ya gene no gutanga ibimenyetso ku turemangingo.

② NAD+ ifasha mu kugenzura kwangirika kwa ADN

Uko ibinyabuzima bigenda bisaza, ibintu bibi bidukikije nk'imirasire, umwanda, no gukora ADN mu buryo butari bwo bishobora kwangiza ADN. Iyi ni imwe mu nyigisho zivuga ku gusaza. Uturemangingo hafi ya twose tuba dufite "imashini zikoresha molekile" kugira ngo dusane iyi ndwara.

Uku gusana bisaba NAD+ n'ingufu, bityo kwangirika gukabije kwa ADN bitwara umutungo kamere w'uturemangingo. Imikorere ya PARP, poroteyine y'ingenzi yo gusana ADN, nayo iterwa na NAD+. Gusaza gusanzwe bituma kwangirika kwa ADN kwiyongera mu mubiri, RARP ikiyongera, bityo igipimo cya NAD+ kikagabanuka. Kwangirika kwa ADN ya Mitochondrial ku ntambwe iyo ari yo yose bizarushaho kwiyongera uku kugabanuka.

③ NAD+bigira ingaruka ku mikorere ya gene Sirtuins iramba kandi ikabuza gusaza

Utunyangingo dushya twavumbuwe tuzwi nka "abarinda utwuma", tugira uruhare runini mu kubungabunga ubuzima bw'utunyangingo. Utwuma duto twa Sirtuin ni umuryango w'imisemburo igira uruhare mu gusubiza ibibazo by'utunyangingo no gusana ibyangiritse. Nanone igira uruhare mu gusohora insuline, gusaza, n'indwara ziterwa no gusaza nk'indwara z'ubwonko na diyabete.

NAD+ ni lisansi ifasha sirtuins kugumana ubuziranenge bwa genome no guteza imbere gusana ADN. Nk'uko imodoka idashobora kubaho idafite lisansi, Sirtuins ikenera NAD+ kugira ngo ikore. Ibisubizo by'ubushakashatsi ku nyamaswa bigaragaza ko kongera urugero rwa NAD+ mu mubiri bikoresha poroteyine za sirtuin kandi bikongera igihe cyo kubaho mu musemburo no mu mbeba.

④ Imikorere y'umutima

Kongera urugero rwa NAD+ birinda umutima kandi bikanatuma imikorere y'umutima irushaho kuba myiza. Umuvuduko ukabije w'amaraso ushobora gutera umutima kwiyongera no kuziba imitsi, ibyo bikaba byatera indwara yo gucika intege. Nyuma yo kongera urugero rwa NAD+ mu mutima binyuze mu nyongera za NAD+, kwangirika k'umutima guterwa no kongera amaraso birahagarikwa. Ubundi bushakashatsi bwagaragaje ko inyongera za NAD+ zirinda imbeba kwaguka k'umutima kudasanzwe.

⑤ Kwangirika kw'ubwonko

Ku mbeba zirwaye indwara ya Alzheimer, kongera urugero rwa NAD+ byongera imikorere y’ubwonko binyuze mu kugabanya ubwiyongere bwa poroteyine zibangamira itumanaho ry’ubwonko. Kongera urugero rwa NAD+ kandi birinda uturemangingo tw’ubwonko gupfa iyo nta maraso ahagije atembera mu bwonko. NAD+ isa nkaho ifite icyizere gishya mu kurinda kwangirika kw’imitsi no kunoza kwibuka.

⑥ Ubudahangarwa bw'umubiri

Uko tugenda dusaza, ubudahangarwa bwacu bw'umubiri bugabanuka kandi turushaho kwibasirwa n'indwara. Ubushakashatsi buherutse gukorwa bwerekana ko urugero rwa NAD+ rugira uruhare runini mu kugena uburyo ubudahangarwa bw'umubiri bukora, ububyimbirwe, ndetse no kubaho kw'uturemangingo mu gihe cy'ubusaza. Ubushakashatsi bwerekana ubushobozi bwa NAD+ mu kuvura indwara zidakora neza z'umubiri.

Isano iri hagati y'uruhare rwa NAD+ n'ubusaza

Koenzyme igira uruhare mu ihinduka ry'ibintu by'ingenzi nk'isukari, ibinure na poroteyine mu mubiri w'umuntu, kandi igira uruhare runini mu kugenzura ihinduka ry'ibintu n'ingufu mu mubiri no kubungabunga imikorere isanzwe y'umubiri. NAD ni koenzyme y'ingenzi cyane mu mubiri w'umuntu, yitwa kandi koenzyme ya mbere. Igira uruhare mu bikorwa ibihumbi bya redox enzyme mu mubiri w'umuntu. Ni ikintu cy'ingenzi mu ihinduka ry'uturemangingo twose. Ifite imirimo myinshi, imirimo y'ingenzi ni iyi:

1. Guteza imbere ikorwa ry'ingufu zikomoka ku binyabuzima

NAD+ ikora ATP binyuze mu guhumeka kw'uturemangingo, yongera ingufu z'uturemangingo kandi ikanoza imikorere y'uturemangingo;

2. Gusana imiterere y'uturemangingo (genes)

NAD+ niyo substrate yonyine ikoreshwa mu gusana ADN enzyme PARP. Ubu bwoko bwa enzyme bugira uruhare mu gusana ADN, bufasha gusana ADN n'uturemangingo twangiritse, bugabanya amahirwe yo guhinduka kw'uturemangingo, kandi bukarinda kanseri;

3. Koresha poroteyine zose ziramba

NAD+ ishobora gukora poroteyine zose 7 zo kuramba, bityo NAD+ igira ingaruka zikomeye ku kurwanya gusaza no kongera igihe cyo kubaho;

4. Kongera imbaraga mu mikorere y'ubudahangarwa bw'umubiri

NAD+ ikomeza ubudahangarwa bw'umubiri kandi ikongera ubudahangarwa bw'uturemangingo binyuze mu kugira ingaruka ku kubaho no ku mikorere y'uturemangingo twa T dushinzwe kugenzura.

5. Guteza imbere imikurire y'umusatsi

Impamvu nyamukuru itera gutakaza umusatsi ni ukubura imbaraga z'uturemangingo tw'umusatsi, kandi kubura imbaraga z'uturemangingo tw'umusatsi ni uko urugero rwa NAD+ mu mubiri w'umuntu rugabanuka. Uturemangingo tw'umusatsi ntabwo dufite ATP ihagije yo gukora poroteyine y'umusatsi, bityo bigatuma umusatsi utakaza imbaraga.

6. Kugabanya ibiro, guteza imbere metabolism

Mu 2017, Porofeseri David Sinclair wo mu Ishuri ry’Ubuganga rya Harvard n’itsinda ryo muri Koleji y’Ubuganga ya Ositaraliya bakoze igerageza ryo kugereranya imbeba z’ingore zibyibushye zikora imyitozo ngororamubiri ku gikoresho cyo gutemberamo mu gihe cy’ibyumweru 9 no gufata NMN buri munsi mu gihe cy’iminsi 18. Ubushakashatsi bwagaragaje ko NMN igira ingaruka ku mikorere y’ibinure mu mwijima. Kandi ingaruka zo gukora imyitozo ngororamubiri zigaragara ko ziruta iz’imyitozo ngororamubiri.

Igishimishije ni uko gusaza bijyana no kugabanuka gukomeye kw'urugero rwa NAD+ mu turemangingo no mu turemangingo mu turemangingo dutandukanye, harimo imbeba n'abantu. Kugabanuka kw'urugero rwa NAD+ bifitanye isano n'indwara nyinshi zijyanye no gusaza, harimo kugabanuka k'ubushobozi bwo gutekereza, kanseri, indwara z'imikorere y'umubiri, sarcopenia, n'ubugwari.

Nigute nakora isuzuma rya NAD+ buri munsi?

Nta ngano itagira ingano ya NAD+ mu mubiri wacu. Ingano n'imikorere ya NAD+ mu mubiri w'umuntu bizagabanuka uko umuntu asaza, kandi bizagabanuka vuba nyuma y'imyaka 30, bigatera gusaza kw'uturemangingo, apoptosis no gutakaza ubushobozi bwo kongera kumera neza.

Byongeye kandi, kugabanuka kwa NAD+ bizatera ibibazo byinshi by’ubuzima, bityo niba NAD+ idashobora kongera kuzura ku gihe, ingaruka zishobora kwirengagizwa.

1.Inyongera ikomoka ku biribwa

Ibiribwa nka amashu, broccoli, avoka, inyama, ibihumyo, na edamame birimo NAD+ precursors, bishobora guhinduka NAD* ikora mu mubiri nyuma yo kwinjiza.

2. Kugabanya indyo n'ibiryo bikomoka ku karori

Kugabanya karori mu rugero bishobora gutuma inzira zo kumenya ingufu mu turemangingo no kongera urugero rwa NAD* mu buryo butaziguye. Ariko menya neza ko urya indyo yuzuye kugira ngo uhuze n'ibyo umubiri wawe ukeneye mu mirire.

3. Komeza gukora siporo no gukora imyitozo ngororamubiri

Imyitozo ngororamubiri iringaniye nko kwiruka no koga ishobora kongera urugero rwa NAD+ mu ngirabuzimafatizo, igafasha kongera umwuka wa ogisijeni mu mubiri no kunoza imikorere y’ingufu.

4. Kurikiza ingeso nziza zo gusinzira

Mu gihe cyo gusinzira, umubiri w'umuntu ukora ibikorwa byinshi by'ingenzi byo gutunganya no gusana, harimo no gukora NAD*. Gusinzira bihagije bifasha kugumana urugero rusanzwe rwa NAD

5. Inyongera ku bintu bya mbere bya NAD+

Aside Nicotine (NA) na nicotinamide (NAM) byombi ni byo byabanjirije NAD+. Bishobora gukorwa no guhinduka NAD mu mubiri w'umuntu, bityo bikongera ingano yayo. Ariko, bitewe n'imbogamizi z'inzira yo gukora ndetse n'imisemburo igabanya umuvuduko, ubushobozi bwo gukora ibintu buri hasi.

6 Inyongera ku buryo butaziguye ya NAD+

Kongera NAD+ hanze bishobora kugarura vuba urugero rwa NAD+ mu mubiri, bigatuma ingingo z'ingenzi nk'umutima n'ubwonko zibona kongerera NAD+ akamaro kurushaho.

Suzhou Myland Pharm & Nutrition Inc. ni uruganda rwemewe na FDA rutanga ifu y’inyongera ya NAD+ nziza kandi isukuye cyane.

Muri Suzhou Myland Pharm twiyemeje gutanga ibicuruzwa byiza cyane ku giciro cyiza. Ifu yacu y'inyongeramusaruro ya NAD+ ipimwa neza kugira ngo imenyekane ko ari nziza kandi ifite imbaraga, bityo ukaba ubona inyongeramusaruro nziza ushobora kwizera. Waba ushaka gufasha ubuzima bw'uturemangingo, kongera ubudahangarwa bw'umubiri wawe cyangwa kongera ubuzima bwiza muri rusange, ifu yacu y'inyongeramusaruro ya NAD+ ni yo mahitamo meza.

Suzhou Myland Pharm imaze imyaka 30 ikora kandi iyobowe n'ikoranabuhanga rigezweho n'ingamba zo gukora ubushakashatsi n'iterambere zinoze cyane, yateje imbere ibicuruzwa bitandukanye kandi iba ikigo gishya gitanga serivisi z'inyongera ku buzima, gukora ibintu bitandukanye no gukora ibikoresho bitandukanye.

Byongeye kandi, Suzhou Myland Pharm ni uruganda rwanditswe na FDA. Imbuga z’ubushakashatsi n’iterambere by’iyi sosiyete, ibikoresho byayo byo gukora, n’ibikoresho byo gusesengura ni ibintu bigezweho kandi bifite imikorere myinshi, kandi bishobora gukora imiti kuva kuri miligarama kugeza kuri toni, kandi bikurikiza amahame ya ISO 9001 n’ibipimo bya GMP mu gukora.