NAD + Niki kandi Kuki Ukeneye Kubuzima Bwawe?

Mwisi yisi igenda yiyongera kubuzima nubuzima bwiza, NAD + yahindutse ijambo ryijambo, bikurura abahanga nabakunda ubuzima. Ariko mubyukuri NAD + ni iki? Kuki ari ngombwa cyane kubuzima bwawe? Reka twige byinshi kubyerekeye amakuru ajyanye hepfo!

NAD + ni iki?

Izina ry'ubumenyi rya NAD ni nicotinamide adenine dinucleotide. NAD + ibaho muri buri selile yumubiri. Nibyingenzi metabolite na coenzyme munzira zitandukanye. Ihuza kandi ikagira uruhare mubikorwa bitandukanye byibinyabuzima. Enzymes zirenga 300 ziterwa na NAD + Gukora.

NAD +ni amagambo ahinnye yicyongereza ya Nicotinamide adenine dinucleotide. Izina ryayo ryuzuye mu gishinwa ni nicotinamide adenine dinucleotide, cyangwa Coenzyme I muri make. Nka coenzyme yanduza hydrogene ion, NAD + igira uruhare mubintu byinshi bigize metabolisme yumuntu, harimo glycolysis, Gluconeogenesis, tricarboxylic aside cycle, nibindi. Ubushakashatsi bumwe bwerekanye ko kugabanuka kwa NAD + bifitanye isano nimyaka, hamwe nuburyo bwa physiologique bwabunzi na NAD + bifitanye isano no gusaza, indwara ziterwa na metabolike, neuropathie na kanseri, harimo kugenzura selile homeostasis, sirtuine izwi nka "kuramba", gusana ADN, poroteyine z'umuryango PARPs zijyanye na necroptose na CD38 zifasha mukumenyesha calcium.

NAD + ikora nka bisi itwara abantu, itwara electron kuva molekile imwe ikajya mubindi. Hamwe na molekuline ya mugenzi we NADH, igira uruhare muburyo butandukanye bwo guhindagurika binyuze mu guhanahana amakuru ya elegitoronike ikora adenosine triphosphate (ATP), molekile "imbaraga" z'umubiri.

Muri make, NAD + ningirakamaro mukubungabunga ubuzima bwumubiri nuburinganire. Metabolism, redox, kubungabunga ADN no kuyisana, gutuza gene, kugenzura epigenetike, nibindi byose bisaba uruhare rwa NAD +.

Kubwibyo, umubiri wacu ukeneye cyane NAD +. NAD + ihora ikomatanya, igacika kandi ikongera gukoreshwa mu ngirabuzimafatizo kugirango igumane urwego ruhamye rwa NAD +.

NAD + nikintu cyingenzi mubikorwa bya selile kandi igira uruhare mugutanga ingufu no gusana ADN, byombi bifitanye isano rya bugufi no gusaza neza.

1) Ikwirakwizwa cyane mu ngirabuzimafatizo zose z'umubiri w'umuntu kandi igira uruhare mu bihumbi ibinyabuzima byangiza. Irashobora guteza imbere metabolisme yisukari, ibinure na aside amine, kandi ikagira uruhare muguhuza ingufu. Ni coenzyme yingenzi ikenewe kumubiri wumuntu.

2) NAD + niyo substrate yonyine ya enzymes ikoresha coI (substrate yonyine ya enzyme yo gusana ADN ya PARP, insimburangingo yonyine ya proteine ​​Sirtuins yo kuramba, hamwe na substrate yonyine ya cyclicale ADP ribose synthase CD38 / 157).

Ariko, uko imyaka igenda yiyongera, urwego rwa NAD + mumubiri rugabanuka vuba. Bizagabanukaho 50% buri myaka 20. Hafi yimyaka 40, NAD + ibirimo mumubiri wumuntu ni 25% gusa mubyo yari iri mubana.

Niba ingirabuzimafatizo zabantu zabuze NAD +, imikorere mibi ya mitochondrial iragabanuka, ubushobozi bwo gusana ADN bwaragabanutse, kandi umuryango muremure wa proteine ​​umuryango Sirtuin nawo ntukora, nibindi. Izi mpamvu mbi zishobora gutera apoptose, indwara zabantu, gusaza ndetse nurupfu.

Uruhare rwa NAD + mubuzima bwawe muri rusange

Kurwanya gusaza

NAD + ikomeza itumanaho ryimiti hagati ya nucleus na mitochondria, kandi itumanaho ridakomeye nimpamvu ikomeye yo gusaza kwa selile.

NAD + irashobora gukuraho umubare wiyongera wa code ya ADN yibeshya mugihe cya metabolisme selile, igakomeza imvugo isanzwe ya gen, igakomeza imikorere isanzwe ya selile, kandi igabanya umuvuduko wo gusaza kwingirangingo zabantu.

Gusana ibyangiritse kuri ADN

NAD + ni insimburangingo yingenzi ya ADN yo gusana enzyme PARP, igira uruhare runini mugusana ADN, imvugo ya gene, iterambere ryimikorere, kubaho kwakagari, kwiyubaka kwa chromosome, no gutuza kwa gene.

Koresha poroteyine yo kuramba

Sirtuins ikunze kwitwa umuryango wa proteine ​​uramba kandi igira uruhare runini mugikorwa cyimikorere, nko gutwika, gukura kwingirabuzimafatizo, injyana ya circadian, imbaraga za metabolisme, imikorere ya neuronal, hamwe no kurwanya imihangayiko, kandi NAD + ni enzyme yingenzi muguhuza poroteyine zo kuramba. .

Ikora poroteyine 7 zose zo kuramba mu mubiri w'umuntu, zigira uruhare runini mukurwanya ingirabuzimafatizo, imbaraga za metabolisme, kwirinda ihinduka ryimiterere ya selile, apoptose no gusaza.

Tanga ingufu

Ihagarika umusaruro urenga 95% yingufu zisabwa mubikorwa byubuzima. Mitochondriya mu ngirabuzimafatizo z'abantu ni imbaraga z'ingirabuzimafatizo. NAD + ni coenzyme yingenzi muri mitochondria kubyara molekile yingufu ATP, ihindura intungamubiri mumbaraga zikenewe numubiri wumuntu.

Guteza imbere imiyoboro y'amaraso no gukomeza imiyoboro y'amaraso

Imiyoboro y'amaraso ni ingirangingo zingirakamaro mubikorwa byubuzima. Mugihe tugenda dusaza, imiyoboro y'amaraso igenda itakaza buhoro buhoro kandi igakomera, ikabyimba, kandi ikagabanuka, bigatera "arteriosclerose."

NAD + irashobora kongera ibikorwa bya elastine mumitsi yamaraso, bityo igakomeza ubworoherane bwimitsi yamaraso no gukomeza ubuzima bwamaraso.

Teza imbere metabolism

Metabolism nigiteranyo cyimikorere itandukanye yimiti mumubiri. Umubiri uzakomeza guhana ibintu ningufu. Iyo uku guhana guhagarara, ubuzima bwumubiri nabwo buzarangira.

Porofeseri Anthony n'itsinda rye ry'ubushakashatsi muri kaminuza ya Kaliforuniya, muri Amerika, basanze NAD + ishobora kunoza neza umuvuduko wa metabolisme y'utugingo ngengabuzima ijyanye no gusaza, bityo ubuzima bw'abantu bukongera ubuzima bwabo.

Rinda ubuzima bwumutima

Umutima ningingo zingenzi zabantu, kandi urwego rwa NAD + mumubiri rufite uruhare runini mugukomeza imikorere isanzwe yumutima.

Kugabanuka kwa NAD + bishobora kuba bifitanye isano no gutera indwara nyinshi zifata umutima-mitsi, kandi umubare munini wubushakashatsi bwibanze nabwo bwemeje ingaruka zo kuzuza NAD + ku ndwara z'umutima.

Irinde indwara z'umutima n'imitsi n'ubwonko

Ubushakashatsi bwerekanye ko hafi ya zose zirindwi za sirtuine (SIRT1-SIRT7) zifitanye isano no kubaho kwindwara zifata umutima. Sirtuins ifatwa nkigitego cya agonistic cyo kuvura indwara zifata umutima, cyane cyane SIRT1.

NAD + niyo substrate yonyine ya Sirtuins. Kwiyongera ku gihe cya NAD + ku mubiri w'umuntu birashobora gukora byimazeyo ibikorwa bya buri bwoko bwa Sirtuins, bityo bikarinda ubuzima bwimitsi yumutima no kwirinda indwara zifata umutima.

Guteza imbere umusatsi

Impamvu nyamukuru itera umusatsi ni ugutakaza umusatsi ubuzima bwimitsi ya nyina, kandi gutakaza imbaraga za mama ya selile ni ukubera ko urwego rwa NAD + mumubiri wumuntu rugabanuka. Utugingo ngengabuzima twimisatsi ntabwo dufite ATP ihagije kugirango ikore synthesis proteine ​​yimisatsi, bityo itakaza imbaraga kandi iganisha kumisatsi.

Kubwibyo, kuzuza NAD + birashobora gushimangira ukwezi kwa acide no kubyara ATP, kugirango uturemangingo twa mama wumusatsi ufite ubushobozi buhagije bwo gukora proteine ​​yimisatsi, bityo bigatuma umusatsi ugabanuka.

Aho Kugura Beta-NAD + Inyongera Kumurongo Kumurongo

Suzhou Myland Pharm & Nutrition Inc ni uruganda rwanditswe na FDA rutanga ubuziranenge bwiza kandi bwera cyane NAD + Ifu yinyongera.

Muri Pharm ya Suzhou Myland twiyemeje gutanga ibicuruzwa byiza cyane kubiciro byiza. Ifu ya NAD + yinyongera irageragezwa cyane kugirango isukure nimbaraga, ikwemeza ko ubona inyongera nziza-nziza ushobora kwizera. Waba ushaka gushyigikira ubuzima bwimikorere, kuzamura sisitemu yumubiri cyangwa kuzamura ubuzima muri rusange, ifu ya NAD + Inyongera ni amahitamo meza.

Hamwe nuburambe bwimyaka 30 kandi itwarwa nubuhanga buhanitse hamwe nuburyo bunoze bwa R&D, Pharm ya Suzhou Myland Pharm yateje imbere ibicuruzwa bitandukanye byapiganiwe kandi ihinduka ubuzima bushya bwa siyanse yubuzima, synthèse progaramu na sosiyete ikora serivise.

Mubyongeyeho, Suzhou Myland Pharm nayo ikora FDA yemewe. Ibikoresho bya sosiyete R&D, ibikoresho byo kubyaza umusaruro, nibikoresho byisesengura nibigezweho kandi byinshi, kandi birashobora gukora imiti kuva kuri miligarama kugeza kuri toni mubipimo, kandi ikubahiriza ibipimo bya ISO 9001 nibisobanuro bya GMP.