NAD+ ni iki kandi kuki uyikeneye ku buzima bwawe?

Mu isi y’ubuzima n’imibereho myiza ikomeje kwiyongera, NAD+ yabaye ijambo rizwi cyane, rikurura ibitekerezo by’abahanga mu bya siyansi n’abakunzi b’ubuzima. Ariko se koko NAD+ ni iki? Kuki ari ingenzi cyane ku buzima bwawe? Reka tumenye byinshi ku makuru ajyanye n’ubuzima hano hepfo!

NAD+ ni iki?

Izina rya siyansi rya NAD ni nicotinamide adenine dinucleotide. NAD+ iboneka muri buri turemangingo tw'umubiri wacu. Ni metabolite y'ingenzi na coenzyme mu nzira zitandukanye za metabolism. Ihuza kandi igira uruhare mu mikorere itandukanye ya biyoloji. Enzymes zirenga 300 zishingiye kuri NAD+ kugira ngo zikore.

NAD+Ni incamake y'Icyongereza ya Nicotinamide adenine dinucleotide. Izina ryayo ryuzuye mu Gishinwa ni nicotinamide adenine dinucleotide, cyangwa Coenzyme I mu magambo ahinnye. Nk'inyongeramusaruro ikwirakwiza iyoni za hydrogen, NAD+ igira uruhare mu bintu byinshi bigize imikorere y'umubiri w'umuntu, harimo glycolysis, Gluconeogenesis, tricarboxylic acid cycle, nibindi. Hari ubushakashatsi bwagaragaje ko kugabanuka kwa NAD+ bifitanye isano n'imyaka, kandi uburyo umubiri uterwa na NAD+ bufitanye isano no gusaza, indwara za metabolic, neuropathy na kanseri, harimo no kugenzura homeostasis y'uturemangingo, sirtuins izwi nka "genes longevity", gusana ADN, poroteyine zo mu muryango wa PARP zijyanye na necroptosis na CD38 ifasha mu gutanga ibimenyetso bya calcium.

NAD+ ikora nk'imodoka itwara amashanyarazi, itwara amashanyarazi ava mu ngirabuzimafatizo imwe ijya mu yindi. Hamwe na NADH, ikora ibikorwa bitandukanye byo guhindura imikorere y'amashanyarazi binyuze mu ihererekanya rya electron rikora adenosine triphosphate (ATP), molecule y'ingufu z'umubiri.

Muri make, NAD+ ni ingenzi cyane mu kubungabunga ubuzima bw'umubiri no kuringaniza. Ihinduka ry'umubiri, redox, kubungabunga no gusana ADN, guhagarara neza kw'uturemangingo, kugenzura epigenetic, nibindi byose bisaba ko NAD+ igira uruhare.

Bityo rero, umubiri wacu ukeneye cyane NAD+. NAD+ ihora ikorwa, igasenyuka kandi igakoreshwa mu turemangingo kugira ngo urwego rwa NAD+ rw’uturemangingo rukomeze kuba rwiza.

NAD+ ni igice cy'ingenzi cy'imikorere y'uturemangingo kandi igira uruhare mu gutanga ingufu no gusana ADN, byombi bifitanye isano rya hafi no gusaza neza.

1) Ikwirakwira cyane mu turemangingo twose tw’umubiri w’umuntu kandi igira uruhare mu bikorwa ibihumbi by’imikorere ya biocatalytic. Ishobora guteza imbere ihinduka ry’isukari, ibinure na aside amine, kandi ikagira uruhare mu gukora ingufu. Ni coenzyme y’ingenzi ikenewe ku mubiri w’umuntu.

2) NAD+ niyo substrate yonyine ikoreshwa mu gukora enzymes zikoresha coI (substrate yonyine ikoreshwa mu gusana ADN enzyme PARP, substrate yonyine ikoreshwa mu gukora poroteyine iramba ya Sirtuins, kandi niyo substrate yonyine ikoreshwa mu gukora cyclic ADP ribose synthase CD38/157).

Ariko, uko imyaka igenda yiyongera, urugero rwa NAD+ mu mubiri rugabanuka cyane. Ruzagabanukaho 50% buri myaka 20. Ku myaka hafi 40, ingano ya NAD+ mu mubiri w'umuntu ni 25% gusa by'uko yari iri mu bana.

Iyo uturemangingo tw’umuntu tudafite NAD+, imikorere mibi ya mitochondrial iragabanuka, ubushobozi bwo gusana ADN yangiritse buragabanuka, kandi umuryango wa poroteyine ya gene Sirtuin nawo ntuba ugikora, nibindi. Ibi bintu bibi bishobora gutera apoptosis, indwara z’abantu, gusaza ndetse n’urupfu.

Uruhare rwa NAD+ mu buzima bwawe muri rusange

Kurwanya gusaza

NAD+ ikomeza itumanaho rya shimi hagati y’ingirabuzimafatizo na mitochondria, kandi itumanaho rike ni impamvu ikomeye ituma ingirabuzimafatizo zisaza.

NAD+ ishobora gukuraho umubare ugenda wiyongera wa ADN zibeshya mu gihe cy’imikorere y’uturemangingo, igakomeza kugaragaza neza imiterere y’uturemangingo, igakomeza gukora neza kw’uturemangingo, kandi igatuma uturemangingo tw’umuntu tugabanuka.

Gusana ibyangiritse bya ADN

NAD+ ni ingenzi cyane mu gusana ADN enzyme PARP, ifite ingaruka zikomeye ku gusana ADN, imikorere y’uturemangingo, iterambere ry’uturemangingo, kubaho kw’uturemangingo, kongera kubaka chromosomes, no kudahinduka kw’uturemangingo.

Koresha poroteyine irambye

Sirtuins zikunze kwitwa umuryango wa poroteyine zo kuramba kandi zigira uruhare runini mu kugenzura imikorere y’uturemangingo, nko kubyimba, gukura kw’uturemangingo, imikorere ya circadian, ingufu, imikorere y’imitsi, no kudahangayika, kandi NAD+ ni enzyme y’ingenzi mu gukora poroteyine zo kuramba.

Ikora poroteyine zose 7 ziramba mu mubiri w'umuntu, igira uruhare runini mu kurwanya stress z'uturemangingo, imikorere y'ingufu, ikumira impinduka mu turemangingo, apoptosis no gusaza.

Tanga ingufu

Itera imbaraga mu gukora ingufu zisaga 95% zikenewe mu bikorwa by'ubuzima. Mitochondria mu turemangingo tw'abantu ni zo ngirabuzimafatizo z'uturemangingo. NAD+ ni coenzyme y'ingenzi muri mitochondria kugira ngo ikore molekile y'ingufu ATP, igahindura intungamubiri mo ingufu zikenewe n'umubiri w'umuntu.

Guteza imbere imiyoboro y'amaraso no gukomeza ubwisanzure bw'imiyoboro y'amaraso

Imitsi y'amaraso ni ingirabuzimafatizo z'ingenzi mu bikorwa by'ubuzima. Uko tugenda dusaza, imitsi y'amaraso igenda itakaza ubushobozi bwayo bwo kwiyoroshya no gukomera, kuba minini, no kuba mito, bigatera "arteriosclerosis".

NAD+ ishobora kongera imikorere ya elastine mu mitsi y'amaraso, bityo igakomeza gukomera kw'imitsi y'amaraso no kubungabunga ubuzima bw'imitsi y'amaraso.

Guteza imbere metabolism

Metabolism ni uruhurirane rw'ibikorwa bitandukanye bya shimi mu mubiri. Umubiri uzakomeza guhanahana ibintu n'ingufu. Iyo iri hagarikwa, ubuzima bw'umubiri nabwo buzarangira.

Porofeseri Anthony n'itsinda rye ry'ubushakashatsi muri Kaminuza ya California, muri Amerika, basanze NAD+ ishobora kunoza neza igabanuka ry'imikorere y'uturemangingo ijyanye no gusaza, bityo ikarushaho kunoza ubuzima bw'abantu no kongera igihe cyo kubaho.

Kurinda ubuzima bw'umutima

Umutima ni urugingo rw'ingenzi cyane mu bantu, kandi urwego rwa NAD+ mu mubiri rugira uruhare runini mu kubungabunga imikorere isanzwe y'umutima.

Kugabanuka kwa NAD+ bishobora kuba bifitanye isano n’inkomoko y’indwara nyinshi z’umutima n’imitsi, kandi ubushakashatsi bwinshi bw’ibanze bwemeje ingaruka zo kongera NAD+ ku ndwara z’umutima.

Kurinda indwara z'umutima n'imitsi yo mu bwonko

Ubushakashatsi bwagaragaje ko ubwoko bwose burindwi bwa sirtuines (SIRT1-SIRT7) bufitanye isano no kurwara indwara z'umutima n'imitsi. Sirtuines zifatwa nk'intego zo kuvura indwara z'umutima n'imitsi, cyane cyane SIRT1.

NAD+ ni yo substrate yonyine ya Sirtuins. Kongera NAD+ ku mubiri w'umuntu ku gihe bishobora gutuma buri bwoko bwa Sirtuins bukora neza, bityo bikarinda ubuzima bw'umutima n'imitsi no gukumira indwara z'umutima n'imitsi.

Guteza imbere imikurire y'umusatsi

Impamvu nyamukuru itera gutakaza umusatsi ni ukubura imbaraga z'uturemangingo tw'umusatsi, kandi kubura imbaraga z'uturemangingo tw'umusatsi ni uko urugero rwa NAD+ mu mubiri w'umuntu rugabanuka. Uturemangingo tw'umusatsi ntabwo dufite ATP ihagije yo gukora poroteyine y'umusatsi, bityo bigatuma umusatsi utakaza imbaraga.

Bityo rero, kongeramo NAD+ bishobora kongera umuzenguruko wa aside no gukora ATP, bityo uturemangingo tw’umusatsi tukagira ubushobozi buhagije bwo gukora poroteyine y’umusatsi, bityo bigatuma umusatsi utakaza neza.

Aho wagura inyongeramusaruro ya Beta-NAD+ mu buryo bwizewe kuri interineti

Suzhou Myland Pharm & Nutrition Inc. ni uruganda rwemewe na FDA rutanga ifu y’inyongera ya NAD+ nziza kandi isukuye cyane.

Muri Suzhou Myland Pharm twiyemeje gutanga ibicuruzwa byiza cyane ku giciro cyiza. Ifu yacu ya NAD+ Supplement irageragezwa cyane kugira ngo imenyekane ko ari nziza kandi ifite imbaraga, bityo ukaba wabona inyunganizi nziza ushobora kwizera. Waba ushaka gufasha ubuzima bw'uturemangingo, kongera ubudahangarwa bw'umubiri wawe cyangwa kongera ubuzima bwiza muri rusange, ifu yacu ya NAD+ Supplement ni yo mahitamo meza.

Suzhou Myland Pharm ifite uburambe bw'imyaka 30 kandi iyobowe n'ikoranabuhanga rigezweho hamwe n'ingamba zo gukora ubushakashatsi n'iterambere zinoze cyane, yateje imbere ibicuruzwa bitandukanye kandi iba ikigo gishya gitanga serivisi z'inyongera ku buzima, gukora ibintu bitandukanye no gukora ibikoresho bitandukanye.

Byongeye kandi, Suzhou Myland Pharm ni uruganda rwanditswe na FDA. Imbuga z’ubushakashatsi n’iterambere by’iyi sosiyete, ibikoresho byayo byo gukora, n’ibikoresho byo gusesengura ni ibintu bigezweho kandi bifite imikorere myinshi, kandi bishobora gukora imiti kuva kuri miligarama kugeza kuri toni, kandi bikurikiza amahame ya ISO 9001 n’ibipimo bya GMP mu gukora.