Spermidine ni iki? Ubuyobozi bworoshye kuri spermidine

Spermidineni ubwoko bwa polyamine. Polyamine ni ntoya, ibinure, polycationic (-NH3 +) biomolecules. Hariho inyamanswa enye nyamukuru mu nyamaswa z’inyamabere: intanga, spermidine, putrescine na cadaverine. Intanga ngabo ni tetramine, spermidine ni triamine, putrescine na cadaverine ni ibya diamine. Imibare itandukanye yitsinda rya amino ibaha imiterere itandukanye ya physiologique.

Spermidine mu bantu

Spermidine ntabwo iba mu masohoro gusa, ahubwo ikwirakwizwa no mu zindi ngingo no mu ngirabuzimafatizo z'umubiri w'umuntu. Intangangore ya spermidine yibanze cyane cyane kubintu bine:

Synt synthesis idasanzwe:

Arginine → putrescine → spermidine ← intanga. Arginine nigikoresho nyamukuru cyo guhuza intanga ngabo. Ihagarikwa na arginase kubyara ornithine na urea. Ornithine noneho ikoreshwa mukubyara putrescine munsi ya ornithine decarboxylase (ODC1). Iyi niyo ntambwe igabanya igipimo), putrescine itanga spermidine munsi ya spermidine synthase (SPDS). Spermidine irashobora kandi kubyara no kwangirika kwintanga.

UpGufata ibyiciro bidasanzwe:

Igabanyijemo ibiryo hamwe na mikorobe yo munda. Ibiribwa bikungahaye kuri spermidine birimo mikorobe y'ingano, natto, soya, ibihumyo, n'ibindi. Indwara ya bagiteri yitwa mikorobe yo mu mara nka Bifidobacterium nayo irashobora guhuza intanga ngabo.

③Catabolism:

Intanga ngabo mu mubiri zigenda zangirika muri spermidine na putrescine na N1-acetyltransferase (SSAT), okiside polyamine (PAO) hamwe na okiside ya amine, mugihe putrescine ihinduka na aside aminobutyric na okiside. Hanyuma, amine ion na karuboni ya dioxyde irabyara kandi igasohoka mumubiri.

Age:

Ubwinshi bwa spermidine ihinduka uko imyaka igenda. Abashakashatsi bapimye ubunini bwa polyamine mu ngingo zinyuranye n’ingingo z’ibyumweru 3, ibyumweru 10 n’ibyumweru 26 by’imbeba basanga ahanini byarakomeje mu mitsi, mu bwonko no muri nyababyeyi. Impinduka mu mara zigabanuka gato uko imyaka igenda ishira, kandi igabanuka cyane muri thymus, spleen, ovary, umwijima, igifu, ibihaha, impyiko, umutima n imitsi. Ntabwo bigoye kuri twe gutekereza ko impamvu zimpinduka zirimo impinduka zimirire, impinduka mumiterere yibimera byo munda, kugabanya ibikorwa bya synthase ya polyamine, nibindi.

Intego karemano ya spermidine

Ni ukubera iki molekile ntoya yoroheje ari ikintu cyingenzi cyumubiri wumuntu? Ibanga mubyukuri riri mumiterere yabyo: Spermidine ni polycationic (-NH3 +) ibinure bya amine ntoya ya molekile ibaho muburyo bwa protonike nyinshi mubihe bya pH physiologique pH, hamwe na ion nziza ikwirakwizwa mumurongo wa karubone. Amashanyarazi, afite ibikorwa bikomeye bya physiologique.

Kubwibyo, yaba acide nucleic, fosifolipide, proteyine za acide zirimo ibisigisigi bya aside, polysaccharide pectique irimo amatsinda ya carboxyl na sulfate, cyangwa neurotransmitters na hormone (dopamine, epinephrine, serotonine, imisemburo ya tiroyide, nibindi) bifite imiterere isa, Birashoboka ko ari intego ya spermidine. guhuza. Abanegura cyane ni:

Acide Nucleic aside:

Ubushakashatsi bwerekanye ko polyamine nyinshi ibaho muburyo bwa polyamine-RNA mu ngirabuzimafatizo, hamwe na 1-4 bihwanye na polyamine iboshye kuri 100 ihwanye na fosifate. Kubwibyo, uruhare runini rwa spermidine rufitanye isano nimpinduka zimiterere nubusobanuro bwa RNA, nko guhindura ibyiciro bitandukanye bya sintezamubiri ya poroteyine bigira ingaruka kumiterere ya kabiri ya mRNA, tRNA na rRNA. Spermidine irashobora kandi gukora "ibiraro" bihamye hagati ya ADN ya kabiri-ya ADN, bikagabanya uburyo bwa radicals yubusa cyangwa izindi miti yangiza ADN, kandi bikarinda ADN kwanduza amashyanyarazi hamwe nimirasire ya X.

Poroteyine:

Spermidine irashobora guhuza poroteyine zitwara ibintu byinshi bibi kandi bigahindura imiterere ya poroteyine, bityo bikagira ingaruka ku mikorere yayo. Ingero zirimo protein kinase / fosifata (ihuza ryingenzi munzira nyinshi zo gutambutsa ibimenyetso), enzymes zigira uruhare muri methylation ya histone na acetylation (bigira ingaruka kumagambo ya gene muguhindura epigenetique), acetylcholinesterase (igice cyingenzi cyindwara zifata ubwonko). umwe mu miti ivura), reseptor ya ion umuyoboro (nka AMPA, reseptor ya AMDA), nibindi

Suzhou Myland ni uruganda rwa FDA rwanditse rutanga ifu ya Spermidine nziza kandi nziza.

Kuri Suzhou Myland, twiyemeje gutanga ibicuruzwa byiza byiza kubiciro byiza. Ifu yacu ya Spermidine irageragezwa cyane kugirango isukure nimbaraga, ikwemeza kubona inyongeramusaruro nziza ushobora kwizera. Waba ushaka gushyigikira ubuzima bwa selile, kuzamura sisitemu yumubiri cyangwa kuzamura ubuzima muri rusange, ifu ya Spermidine niyo ihitamo neza.

Hamwe nuburambe bwimyaka 30 kandi itwarwa nubuhanga buhanitse hamwe nuburyo bunoze bwa R&D, Spermidine yateje imbere ibicuruzwa bitandukanye byapiganwa kugirango ibe inyongera yubumenyi bwubuzima bushya, synthèse yihariye na sosiyete ikora ibikorwa.

Mubyongeyeho, Suzhou Myland nayo ikora FDA yemewe. Ibikoresho bya sosiyete R&D, ibikoresho byububiko, nibikoresho byisesengura nibigezweho kandi nibikorwa byinshi, kandi birashobora gukora imiti kuva kuri miligarama kugeza kuri toni mubipimo, kandi ikubahiriza ibipimo bya ISO 9001 nibisobanuro bya GMP.