Intanga ni iki? Ubuyobozi bworoshye bwo gutanga intanga

Spermidineni ubwoko bwa polyamine. Polyamine ni biomolecule nto, zirimo ibinure byinshi, zigizwe na polycationic (-NH3+). Hari polyamine enye z'ingenzi mu nyamaswa: spermine, spermidine, putrescine na cadaverine. Intanga ngabo ni iya tetramine, spermidine ni iya triamine, putrescine na cadaverine ni iya diamine. Umubare utandukanye w'amatsinda y'amine utanga imiterere itandukanye y'umubiri.

Spermidine mu bantu

Spermidine ntiboneka mu masohoro gusa, ahubwo ikwirakwira no mu zindi ngingo n'uturemangingo tw'umubiri w'umuntu. Ingano y'intanga mu ngirabuzimafatizo iterwa ahanini n'ibintu bine:

①Guhuza kw'uturemangingo:

Arginine → putrescine → spermidine ← spermine. Arginine ni yo ngirabuzimafatizo nyamukuru mu gukora spermidine mu turemangingo. Ikoreshwa na arginase kugira ngo ikore ornithine na urea. Hanyuma Ornithine ikoreshwa mu gukora putrescine ikoresheje ornithine decarboxylase (ODC1). Iyi ni intambwe igabanya igipimo, putrescine ikora spermidine ikoresheje spermidine synthase (SPDS). Spermidine ishobora kandi gukorwa no kwangirika kw'intanga.

②Gukurura hanze y'uturemangingo:

Bigabanyijemo ibice byo kurya no gukora mikorobe mu mara. Ibiribwa bikungahaye kuri spermidine birimo ingano, natto, soya, ibihumyo, nibindi. Intanga ngabo n'imbuto z'umura biva mu biribwa byinjira vuba mu mara kandi bigakwirakwira nta kwangirika, bityo ingano y'imbuto z'umura mu maraso. Ingano ziratandukanye cyane. Bagiteri za probiotic mu mikorobe zo mu mara nka Bifidobacterium nazo zishobora gukora spermidine.

③Katabolisme:

Intanga ngabo mu mubiri zigenda zihinduka spermidine na putrescine binyuze muri N1-acetyltransferase (SSAT), polyamine oxidase (PAO) n'izindi amine oxidases, mu gihe putrescine irushaho guhindurwamo aside aminobutyric binyuze muri oxidases. Amaherezo, iyoni za amine na dioxyde de carbone bivanwa mu mubiri kandi bigasohoka.

④Imyaka:

Ingano y'umusemburo w'imbuto z'umura irahinduka uko imyaka igenda ishira. Abashakashatsi bapimye ingano ya polyamine mu ngingo zitandukanye n'ingingo z'imbeba zifite ibyumweru 3, ibyumweru 10 na 26, maze basanga ahanini iguma mu ipanjisi, ubwonko na nyababyeyi. Impinduka mu mara zigabanuka gato uko imyaka igenda ishira, kandi zikagabanuka cyane mu mitsi ya thymus, spleen, ovary, umwijima, igifu, ibihaha, impyiko, umutima n'imitsi. Ntibigoye gutekereza ko impamvu z'iyi mpinduka zirimo impinduka mu mirire, impinduka mu miterere y'ibimera byo mu mara, kugabanuka k'imikorere ya polyamine synthase, nibindi.

Intego karemano y'imisemburo

Kuki molekile ntoya nk'iyi ari ikintu cy'ingenzi ku mubiri w'umuntu? Ibanga riri mu miterere yayo: Spermidine ni molekile ntoya ya polycationic (-NH3+) igizwe n'amavuta menshi iboneka mu buryo bufite protonation nyinshi mu gihe cy'imiterere ya pH, hamwe na iyoni nziza zikwirakwizwa mu ruhererekane rwa karuboni. Umuriro w'amashanyarazi, ufite imikorere ikomeye ya fiziki.

Bityo rero, byaba ari aside nucleic, phospholipide, poroteyine aside irimo ibisigazwa bya aside, polysaccharides pectic irimo amatsinda ya carboxyl na sulfates, cyangwa neurotransmitters na hormones (dopamine, epinephrine, serotonin, hormone ya tiroyide, nibindi) bifite imiterere isa, bishobora kuba intego yo guhuza spermidine. Iby'ingenzi cyane ni ibi bikurikira:

① Aside ya nucleike:

Ubushakashatsi bwagaragaje ko polyamine nyinshi ziba mu buryo bwa polyamine-RNA complexes mu turemangingo, hamwe na polyamine ingana na 1-4 kuri polyamine 100 ingana na fosfeti. Kubwibyo, uruhare runini rwa spermidine rufitanye isano n'impinduka mu miterere no mu guhindura RNA, nko kugira ingaruka ku byiciro bitandukanye byo gukora poroteyine binyuze mu kugira ingaruka ku miterere ya kabiri ya mRNA, tRNA na rRNA. Spermidine ishobora kandi gukora "ibiraro" bihamye hagati y'imirongo ya ADN ifite uruziga rubiri, ikagabanya ubushobozi bwo kugera kuri radicals yigenga cyangwa izindi ADN zangiza, no kurinda ADN kwangirika k'ubushyuhe n'imirasire ya X-ray.

②Poroteyine:

Spermidine ishobora gufatana na poroteyine zitwara amashanyarazi akomeye kandi igahindura imiterere y’aho poroteyine iherereye, bityo ikagira ingaruka ku mikorere yayo. Ingero zirimo poroteyine kinase/phosphatase (isano y'ingenzi mu nzira nyinshi zo gutanga ibimenyetso), enzymes zigira uruhare muri methylation ya histone na acetylation (bigira ingaruka ku mikorere ya gene binyuze mu guhindura epigenetics), acetylcholinesterase (igice cy'ingenzi cy'indwara zo kwangirika kw'imitsi). Imwe mu miti ivura), receptors za ion channel (nka AMPA, receptors za AMDA), n'izindi.

Suzhou Myland ni uruganda rwemewe na FDA rutanga ifu ya Spermidine nziza kandi isukuye cyane.

Muri Suzhou Myland, twiyemeje gutanga ibicuruzwa byiza cyane ku giciro cyiza. Ifu yacu ya Spermidine irageragezwa neza kugira ngo imenyekane ko ari nziza kandi ifite imbaraga, bityo ukaba wabona inyongeramusaruro nziza ushobora kwizera. Waba ushaka gufasha ubuzima bw'uturemangingo, kongera ubudahangarwa bw'umubiri wawe cyangwa kongera ubuzima bwiza muri rusange, ifu yacu ya Spermidine ni yo mahitamo meza.

Ifite uburambe bw'imyaka 30 kandi iyobowe n'ikoranabuhanga rigezweho hamwe n'ingamba zo gukora ubushakashatsi n'iterambere zinoze cyane, Spermidine yateguye ibicuruzwa bitandukanye bihiganwa kugira ngo ibe ikigo gishya gitanga serivisi z'ubumenyi bw'ubuzima, gukora ibintu byihariye no gukora.

Byongeye kandi, Suzhou Myland ni uruganda rwanditswe na FDA. Imbuga z’ubushakashatsi n’iterambere by’iyi sosiyete, ibikoresho byayo byo gukora, n’ibikoresho byo gusesengura ni ibintu bigezweho kandi bifite imikorere myinshi, kandi bishobora gukora imiti kuva kuri miligarama kugeza kuri toni, kandi bikurikiza amahame ya ISO 9001 n’ibipimo bya GMP mu gukora.