Ni ubuhe butumwa bwa telomerase bukora-cycloastraganol?

Mu 1985, Greider n'abandi. ubanza kuvumbura telomerase, kandi iyi misemburo mishya yavumbuwe irashobora kongeramo ADN gusubiramo kumpera ya chromosomes kugirango ikomeze uburebure bwa telomere. Telomerase ni ribonucleoprotein igizwe na catalitiki yibanze irimo TERT na TERC, muriyo TERT nurufunguzo rwo kugenzura ibikorwa bya telomerase. Uburebure bwa Telomere bukomeje kugabanuka uko selile zigabanije. Iyo igeze ku gaciro gakomeye, itera ibimenyetso byangiza ADN, biganisha ku ngirabuzimafatizo ngufi ndetse n'indwara ziterwa no kunanirwa kw'inyama zirangwa na telomereri ngufi.

Mu mwaka wa 2010, isosiyete y'Abanyamerika Geron yakoranye na kaminuza y’ubumenyi n’ikoranabuhanga ya Hong Kong mu mushinga w’ubushakashatsi bwo kwerekana abakora televiziyo. Byagaragaye kocycloastraganolIrashobora gukora ibikorwa bya telomerase no gutera kwaguka kwa telomere. Ubu buvumbuzi bwateje imbere cyane iterambere rya telomerase. Iterambere ryubushakashatsi niterambere ryibicuruzwa bijyanye na alcool ya astragalus. Cycloastragenol (CAG) kuri ubu niyo yonyine itanga amakuru ya telomerase mu bicuruzwa bisanzwe. Irashobora kurwanya neza kugabanuka kwa telomere kandi ikagira kurwanya gusaza, kurwanya apoptose, anti-fibrosis, kugenzura ubudahangarwa bw'umubiri, guteza imbere ikwirakwizwa ry'uturemangingo no gukira ibikomere, n'ibindi. Ingaruka za farumasi, bityo zikagira ingaruka zo kuvura indwara ziterwa no kudakora neza kwa telomere.

Cycloastragenol no gusaza

telomeres
Telomeres nuburyo bwihariye kumpera ya chromosomes irinda chromosomes kandi igabanya hamwe na chromosome yigana no kugabana selile. Ingirabuzimafatizo nazo zirasaza nkuko telomeres igabanya.

telomerase
Telomerase irashobora guhuza telomereri kugirango ihagarike uburebure n'imiterere ya telomereri, bityo irinde chromosomes kandi itinde gusaza kwa selile.

Kurwanya gusaza: Umuyoboro wa telomerase, ugira ingaruka zo kurwanya gusaza wongera telomerase bityo ugatinda kugabanuka kwa telomereri.

Telomeres ni imipira iherereye kumpera ya selile chromosomes ibarinda kwangirika mugihe cyo kugabana. Mugihe ingirabuzimafatizo zikomeje kugabana, telomereri ikomeza kugabanuka, igera aho igoye aho ingirabuzimafatizo zizasaza cyangwa zipfa. Telomerase irashobora kwagura uburebure bwa telomereri, kandi igihe cyama selile kiziyongera muburyo bukwiye.

Gusaza ni igice byanze bikunze mubuzima; icyakora, abashakashatsi barimo kwiga uburyo butandukanye bwo kugerageza kwirinda zimwe mu ngaruka zo gusaza, harimo no kwiga senolitike. Senolytike ni ibice bikuraho selile (gusaza) kandi byagaragaye ko bigabanya ingaruka zo gusaza. Ubushakashatsi bushya bwerekana ko cycloastraganol igira ingaruka zo kurwanya gusaza.

Ubushakashatsi bwaturutse mu Bushinwa kandi bwasohotse mu kinyamakuru mpuzamahanga cy’ubumenyi bwa Molecular, bwibanze ku ngirabuzimafatizo z'umuntu n'imbeba zifite imirasire iterwa n'imirasire. Cycloastragenol igabanya ingirabuzimafatizo zitagira ingaruka ku ngirabuzimafatizo. Kuvura Cycloastragenol bigabanya kandi poroteyine mu ngirabuzimafatizo zikenera gukura no kubaho. Ikigeretse kuri ibyo, irabuza ingirabuzimafatizo zijyana n'imyaka hamwe n'ingirabuzimafatizo. Imbeba zashaje zavuwe na cycloastraganol wasangaga zifite selile nkeya kandi zinonosora imikorere yumubiri.

Cycloastragenol igabanya selile

Senescence ni ikimenyetso kizwi cyo gusaza, ariko abashakashatsi basanze gukuraho ingirabuzimafatizo za senescent hamwe na molekile zabo zerekana ibimenyetso bishobora gufasha kwirinda indwara ziterwa n'imyaka ndetse bikanabihindura rimwe na rimwe. Hano, abashakashatsi bavuraga selile zabantu bakoresheje cycloastraganol basanga yaranduye neza ingirabuzimafatizo zidafite ingaruka ku ngirabuzimafatizo zitari senescent. Byongeye kandi, ibimenyetso bya selile byingirabuzimafatizo byagabanutse cyane nyuma yo kuvura cycloastraganol.

Ubushakashatsi bwakozwe mbere bwerekanye ko inzira ya PI3K / AKT / mTOR - inzira yerekana uruhare mu mikurire y’utugingo no kubaho - igira uruhare mu gutwika ibintu byatangijwe na selile senescent, bifasha guteza imbere senescence mu tugari dukikije. Abashakashatsi basanze cycloastragenol yafashije kugabanya poroteyine muri iyi nzira, bavuga ko uruganda rushobora gukora mu guhagarika inzira ya PI3K / AKT / mTOR kugira ngo ifashe kwirinda gusaza. Byongeye kandi, cycloastragenol yerekanwe kugabanya ubushobozi bwingirabuzimafatizo za senescent zo guteza imbere senescence binyuze mu kurekura molekile zitera umuriro, ibintu bikura, hamwe na immunomodulator, bihuje nibyifuzo byerekana ko kugabanya ibimenyetso bya PI3K, AKT, na mTOR bishobora kugabanya ingaruka ziterwa na senescence mu tugari dukikije .

Cycloastragenol ni iya triterpene saponine kandi iboneka cyane muri hydrolysis ya astragaloside IV. Ifite uburemere buke bwa molekuline hamwe na lipofilique ikomeye, ifitiye akamaro kwinjira muri biofilm no kwinjiza gastrointestinal kugirango igere kuri bioavailable nziza. Ingaruka za cycloastragalinol
1. Kuvura ibyangiritse mu bwonko
2. Kunoza fibrosis yumwijima
3. Kuvura ostéoporose
4. Ingaruka zo kurwanya gusaza
5. Gutinda gusaza kwa selile

Ni ukubera iki ari ngombwa guhuza cycloastraganol?

① Cycloastraganol igira ingaruka zitandukanye za farumasi nko guhagarika ubwonko bwa apoptose yubwonko na neuroinflammation mugihe cyubwonko bwubwonko no gukomeza inzitizi yubwonko bwamaraso.
② Cycloastragenol niyo yonyine ya molekile ntoya ya terpenoid hamwe nibikorwa bya telomerase yavumbuwe kugeza ubu kandi irashobora kuvura indwara zifata ubwonko.
Has Ifite ingaruka zo guhagarika fiboside ya myocardial no kongera ubudahangarwa bw'umubiri. Ni molekile izwi cyane mubushakashatsi no guteza imbere imiti irwanya gusaza.

Ibibazo biriho

Ibiri muri cycloastraganol muri Astragalus membranaceus ni bike cyane kandi biragoye kubibona muburyo butaziguye. Ingamba zisanzwe za cycloastraganol zishingiye ku kuvoma imiti gakondo yo mu Bushinwa, iboneka cyane cyane mu guhindura astragaloside IV muri membrane ya Astragalus. Ni ukuvuga, astragaloside IV iboneka binyuze mu gutera ibiti bya astragalus hamwe n’ikoranabuhanga ry’umuco wa tissue, hanyuma astragaloside IV ihindurwamo cycloastragaloside ikoresheje acideolysis, degradation ya Smith, enzyme na hydrolysis ya mikorobe. Nyamara, ubu buryo bwo kwitegura buhenze, bworoshye guteza umwanda ibidukikije, bigoye gutandukanya no kweza, kandi ntabwo bifasha kubishyira mubikorwa no kuzamura. Kubwibyo, abantu berekeje ibitekerezo byabo kuri synthèse artificiel ya cycloastraganol.

Nigute ushobora gukoresha ibinyabuzima byogukora kugirango uhuze? --- Ibinyabuzima bya sintetike

Ibinyabuzima bya sintetike bivuga igishushanyo mbonera, guhinduka, ndetse no kurema "ubuzima bwubukorikori" hamwe nimirimo idasanzwe iyobowe nibitekerezo byubwubatsi, ni ukuvuga ubwubatsi bwa biologiya. Muri rusange, byakozwe hakoreshejwe uburyo bwibinyabuzima.