Ni iki kinyabutabire cya telomerase activator-cycloastraganol cyavumbuwe ubu?

Mu 1985, Greider n'abandi bavumbuye bwa mbere telomerase, kandi iyi enzyme nshya yavumbuwe ishobora kongeramo ADN repeats ku mpera za chromosomes kugira ngo igumane uburebure bwa telomere. Telomerase ni complexe ya ribonucleoprotein ifite ishingiro rya catalytic ririmo TERT na TERC, aho TERT ari ingenzi mu kugenzura imikorere ya telomerase. Uburebure bwa telomere bukomeza kugabanuka uko uturemangingo twigabanyamo ibice. Iyo igeze ku gaciro gakomeye, itera ibimenyetso bya ADN kwangirika, bigatera kugabanuka k'uruhererekane rw'uturemangingo n'urukurikirane rw'indwara zo kunanirwa kw'ingingo zirangwa na telomere ngufi.

Mu 2010, isosiyete y’Abanyamerika Geron yakoranye na Kaminuza ya Hong Kong y’Ubumenyi n’Ikoranabuhanga mu mushinga w’ubushakashatsi bwo gusuzuma ibikoresho bitera telomerase. Byagaragaye kocycloastraganolishobora gukora imikorere ya telomerase no gutuma telomere ikura. Ubu bushakashatsi bwateje imbere iterambere rya telomerase activators. Iterambere ry'ubushakashatsi n'iterambere ry'ibikomoka ku nzoga ya astragalus. Cycloastragenol (CAG) ni yo yonyine yavuzwe mu gukora telomerase activator mu bicuruzwa karemano. Ishobora kurwanya neza telomere igabanuka kandi ifite kurwanya gusaza, kurwanya apoptosis, kurwanya fibrosis, kugenzura ubudahangarwa bw'umubiri, guteza imbere ikwirakwira ry'uturemangingo no gukira ibikomere, nibindi. Ingaruka z'imiti, bityo ikaba igira ingaruka zishobora kuvura indwara zijyanye no kudakora neza kwa telomere.

Cycloastragenol n'ubusaza

telomere
Telomere ni imiterere yihariye iri ku mpera za chromosomes irinda chromosomes kandi ikagabanuka hamwe no kwiyongera kwa chromosomes no kwigabanyamo uturemangingo. Uturemangingo natwo turasaza uko telomeres zigabanuka.

telomerase
Telomerase ishobora gukora telomere kugira ngo ihamye uburebure n'imiterere ya telomere, bityo ikarinda chromosomes kandi igatinza gusaza kw'uturemangingo.

Kurwanya gusaza: Iterambere rya telomerase, rigira ingaruka zo kurwanya gusaza binyuze mu kongera telomerase bityo rigatinza kugabanuka kwa telomere.

Telomere ni udupfundikizo tuba ku mpera za chromosomes z'ingirabuzimafatizo tuzirinda kwangirika mu gihe cyo kwigabanyamo ibice by'ingirabuzimafatizo. Uko ingirabuzimafatizo zikomeza kwigabanyamo ibice, telomere zikomeza kugabanuka, zikagera ku rwego rwo hejuru aho ingirabuzimafatizo zizasaza cyangwa zigapfa. Telomereze ishobora kongera uburebure bwa telomere, kandi igihe cyo kubaho cy'ingirabuzimafatizo kiziyongera mu buryo busanzwe.

Gusaza ni igice cy’ubuzima kidasubirwaho; icyakora, abashakashatsi barimo kwiga uburyo butandukanye bwo kuvura kugira ngo bagerageze kwirinda zimwe mu ngaruka zo gusaza, harimo no kwiga ku miti igabanya ubukana bw’uturemangingo. Imiti igabanya ubukana bw’uturemangingo kandi byagaragaye ko igabanya ingaruka zo gusaza. Ubushakashatsi bushya bwerekana ko cycloastraganol igira ingaruka zo kurwanya ubusaza.

Ubushakashatsi bwakorewe mu Bushinwa, bwasohotse mu kinyamakuru mpuzamahanga cy’ubumenyi bw’ibinyabutabire, bwibanze ku turemangingo tw’abantu n’imbeba zifite ubukure buterwa n’imirasire. Cycloastragenol igabanya uturemangingo tw’ubukure hatitawe ku turemangingo tutari ubukure. Ubuvuzi bwa Cycloastragenol bugabanya kandi poroteyine mu turemangingo tw’ubukure bukenewe kugira ngo uturemangingo dukure kandi tubeho. Byongeye kandi, bubuza urujya n’uruza rw’uturemangingo rufitanye isano n’uturemangingo n’imikorere y’uturemangingo. Imbeba zashaje zavuwe na cycloastraganol byagaragaye ko zifite uturemangingo duke tw’ubukure kandi zigatuma imikorere mibi y’umubiri irushaho kuba myiza.

Cycloastragenol igabanya uturemangingo tw’ubukure

Kugeza ku myaka ni ikimenyetso kizwi cyo gusaza, ariko abashakashatsi basanze gukuraho uturemangingo tw’ubukure n’uturemangingo twabyo dutuma habaho ubushyuhe bishobora gufasha gukumira indwara ziterwa no gusaza ndetse no kuzisubiza inyuma mu bihe bimwe na bimwe. Aha, abashakashatsi bavuje uturemangingo tw’abantu bakoresheje cycloastraganol kandi basanga ikuraho neza uturemangingo tw’ubukure tudafite ingaruka ku turemangingo tutari tw’ubukure. Byongeye kandi, ibimenyetso by’uturemangingo tw’uturemangingo tw’ubukure byagabanutse cyane nyuma yo kuvurwa na cycloastraganol.

Ubushakashatsi bwakozwe mbere bwagaragaje ko inzira ya PI3K/AKT/mTOR—inzira y’ibimenyetso igira uruhare mu gukura no kubaho kw’uturemangingo—igira uruhare mu bikorwa byo kubyimba byatangijwe n’uturemangingo tw’inararibonye, ​​bigafasha mu guteza imbere gusaza mu turemangingo tuyikikije. Abashakashatsi basanze cycloastragenol yafashije kugabanya poroteyine muri iyi nzira, bigaragaza ko iki kinyabutabire gishobora gukora mu guhagarika inzira ya PI3K/AKT/mTOR kugira ngo kifashe mu gukumira gusaza. Byongeye kandi, cycloastragenol byagaragaye ko igabanya ubushobozi bw’uturemangingo tw’inararibonye bwo guteza imbere gusaza binyuze mu kurekura molekile zitera ububyimbirwe, ibintu bikura, n’ibikoresho byo gukumira indwara, hakurikijwe ibitekerezo by’uko kugabanya PI3K, AKT, na mTOR bishobora kugabanya ingaruka zitera gusaza mu turemangingo tuyikikije.

Cycloastragenol ni iya triterpene saponins kandi iboneka cyane cyane mu gushonga kwa astragaloside IV. Ifite uburemere buke bwa molekile kandi ifite lipophilicity ikomeye, ikaba ingirakamaro mu kwinjira muri biofilm no kwinjiza mu gifu kugira ngo igere ku binyabuzima bihari neza. Akamaro ka cycloastragalinol
1. Kuvura ibyangiritse mu bwonko
2. Kunoza umwijima utera indwara ya fibrosis
3. Kuvura indwara yo gucika kw'amagufwa (osteoporosis)
4. Ingaruka zo kurwanya gusaza
5. Gutinda gusaza kw'uturemangingo

Kuki ari ngombwa gukora cycloastraganol?

① Cycloastraganol ifite ingaruka zitandukanye mu by'imiti nko kubuza apoptosis y'uturemangingo tw'ubwonko no kubyimba kw'ubwonko mu gihe cyo kubura amaraso mu bwonko no kubungabunga umuyoboro w'amaraso n'ubwonko.
② Cycloastragenol ni yo molekile ntoya ya terpenoid ifite imikorere ya telomerase yavumbuwe kugeza ubu kandi ishobora kuvura indwara zo kwangirika kw'imitsi.
③ Ifite ingaruka zo kugabanya fibrosis y'umutima no kongera ubudahangarwa bw'umubiri burwanya ikibyimba. Ni molekile ikunzwe cyane mu bushakashatsi no mu iterambere ry'imiti irwanya gusaza.

Ibibazo bihari

Ingano ya cycloastraganol muri Astragalus membranaceus ni nke cyane kandi biragoye kuyibona mu buryo butaziguye. Ingamba zo gukora cycloastraganol zishingiye ku gukurura imiti gakondo y’Abashinwa, ahanini iboneka binyuze mu guhindura astragaloside IV muri Astragalus membranaceus. Ni ukuvuga ko astragaloside IV iboneka binyuze mu ikoranabuhanga ryo gutera astragalus no guteza imbere imiterere y’uturemangingo, hanyuma astragaloside IV igahindurwamo cycloastragaloside hakoreshejwe acidolysis, Smith degradation, enzyme na mikorobe hydrolysis. Ariko, ubu buryo bwo gutegura burahenze, bworoshye guteza umwanda ku bidukikije, bugoye gutandukanya no gutunganya, kandi ntibufasha mu kuyikoresha no kuyiteza imbere. Kubwibyo, abantu berekeje ibitekerezo byabo ku gukora cycloastraganol mu buryo bw’ubukorano.

Ni gute wakoresha biology y'ubukorano mu guhuza imikorere? --- Biology y'ubukorano

Biology y’ubuvanganzo yerekeza ku gishushanyo mbonera, impinduka, ndetse no kurema "ubuzima bw’ubukorano" bufite imikorere idasanzwe buyobowe n’ibitekerezo by’ubuhanga, ni ukuvuga ikoranabuhanga ry’ibinyabuzima. Muri rusange, bikorwa hakoreshejwe uburyo bw’ibinyabuzima.