YDL223C (HBT1) ifu ikora ifu CAS No.: 489408-02-8 99% isuku min. kubintu byongeweho

HBT1 ihuza ligand-ihuza indangarubuga ya α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic aside reseptor (AMPA-R) muburyo bushingiye kuri glutamate. Ibi bivuze ko HBT1 ari molekile ishobora guhuza gusa kurubuga runaka kuri poroteyine ya AMPA-R mugihe glutamate ihari, kandi guhuza bifasha kugenzura ibikorwa bya poroteyine. Kwakira AMPA bigaragarira muri sisitemu yo hagati yo hagati kandi bigira uruhare runini mu itumanaho rya neuronal, gutunganya ibyiyumvo, kwiga, kwibuka, hamwe na plastike ya synaptic. Kwakira AMPA ni uruhare runini mu gushimisha neurotransmission, guhuza byihuse, kwihuta kwishimisha kuri synaps nyinshi, kandi bigira uruhare mubisubizo hakiri kare kuri glutamate mukarere ka synaptic. Abakira AMPA bakunze gufatanya hamwe na NMDA yakira muri synaps, kandi hamwe bateza imbere inzira ya plastike ya synaptique igira uruhare mukwiga, kwibuka, excitotoxicity, na neuroprotection. Ubwonko bukomoka mu bwonko (BDNF) ni ikintu cyitwa neurotrophique kigira uruhare runini mu kubungabunga no kwaguka kwa neurone kandi gifite ingaruka zikomeye kandi nyinshi ku ikwirakwizwa, gutandukana, kubaho no gupfa kw'uturemangingo twa neuronal na non-neuronal. , moderi ya neurotransmitter igira uruhare muri plastike ya neuronal mukwiga no kwibuka. Kubwibyo, ni ngombwa kubuzima n'imibereho myiza ya sisitemu y'imitsi.