YDL223C (HBT1) ifu ikora ifu CAS No.: 489408-02-8 99% isuku min.kubintu byongeweho
Ibipimo byibicuruzwa
| Izina RY'IGICURUZWA | HBT1 |
| Irindi zina | YDL223C |
| URUBANZA No. | 489408-02-8 |
| Inzira ya molekulari | C16H17F3N4O2S |
| Uburemere bwa molekile | 386.40 |
| Isuku | 99.0% |
| Kugaragara | Umuhondo woroshye |
| Gupakira | 1kg kumufuka 25kg kurugoma |
| Gusaba | nootropics |
Kumenyekanisha ibicuruzwa
HBT1 ihuza ligand-ihuza indangarubuga ya α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic aside reseptor (AMPA-R) muburyo bushingiye kuri glutamate.Ibi bivuze ko HBT1 ari molekile ishobora guhuza gusa kurubuga runaka kuri poroteyine ya AMPA-R mugihe glutamate ihari, kandi ko guhuza bifasha kugenzura ibikorwa bya poroteyine.Kwakira AMPA bigaragarira muri sisitemu yo hagati yo hagati kandi bigira uruhare runini mu itumanaho rya neuronal, gutunganya ibyiyumvo, no kwiga, kwibuka, hamwe na plastike ya synaptic.Kwakira AMPA ni uruhare runini mu gushimisha neurotransmission, guhuza byihuse, byihuse byihutirwa bya synaps nyinshi, kandi bigira uruhare mubisubizo hakiri kare by'uturere twa synaptic kugirango glutamate.Abakira AMPA bakunze guhuzwa hamwe na reseptor ya NMDA kuri synapses, kandi hamwe bateza imbere inzira ya plastike ya synaptique igira uruhare mukwiga, kwibuka, excitotoxicity, na neuroprotection.
Ikiranga
Ubwonko bukomoka ku bwonko bukomoka ku bwonko (BDNF) ni ikintu cyitwa neurotrophique kigira uruhare runini mu kubungabunga no kwaguka kwa neurone, kandi gifite ingaruka zikomeye kandi nyinshi ku ikwirakwizwa, gutandukana, kubaho no gupfa kw'uturemangingo twa neuronal na non-neuronal, Ibyakozwe nka moderi ya neurotransmitter kandi igira uruhare muri plastike ya neuronal yo kwiga no kwibuka.Ni ngombwa rero ku buzima no kumererwa neza kwa sisitemu y'imitsi.Ubwiyongere bwa BDNF bushobora kwerekana ko bufasha mu kuvura no gukumira indwara nyinshi.
Porogaramu
HBT1 nigitabo gishya cya reseptor ya AMPA hamwe na agonism yo hasi ugereranije na LY451395 na OXP1, itera umusaruro wubwonko bukomoka mubwonko bukomoka kuri neurotrophique (BDNF), kandi bugaragaza ingaruka nke muri neurone yibanze ya Agitation.HBT1 ihuza indangarubuga ya AMPA-R muburyo bwa glutamate.Hamwe na hamwe, bateza imbere synaptic ya plastike igira uruhare mukwiga, kwibuka, gushimishwa na neuroprotection.Irashobora kunoza ubushobozi bwo kumenya no kwibuka ubwonko, kandi ikongerera abantu ubushobozi bwo kwiga.
