7,8-Dihydroxyflavone ni ikintu gisanzwe kiboneka mu bimera cyakunzwe cyane kubera akamaro kacyo ku mikorere y'ubwonko no kwibuka. Iki kintu gikomoka kuri flavone kiri mu bwoko bw'ibinyabutabire byitwa flavonoids, bizwiho ubushobozi bwabyo bwo kurwanya antioxidant no kurwanya ububyimbirwe. Ubushakashatsi bwagaragaje ko 7,8-dihydroxyflavone ishobora kugira ingaruka nziza nyinshi ku bwonko.
7,8-Dihydroxyflavone ni ikintu gikomeye kandi gifite ubushobozi bwo gukora ibintu byinshi kigize umuryango wa flavonoid. Flavonoids ni ibintu karemano bikwirakwira cyane mu bimera kandi bigira uruhare runini mu mikorere itandukanye y’ibinyabuzima. Imwe mu mico itangaje ya 7,8-dihydroxyflavone ni ubushobozi bwayo bwo gukorana no kugenzura poroteyine na enzymes mu mubiri, ibi bikaba byarakuruye abahanga mu bya siyansi.
Ubushakashatsi bwagaragaje ko ikinyabutabire cya 7,8-dihydroxyflavone gifite akamaro gakomeye ku buzima, gifite ubushobozi bwo kurwanya ubushyuhe, kurwanya ububyimbirwe no kurinda ubwonko. Muri byo, imikorere ikomeye ya 7,8-dihydroxyflavone ituma ishobora gukuraho uturemangingo twangiza umubiri no gukumira stress ya oxidative yangiza uturemangingo ndetse n'indwara zitandukanye. Ubushakashatsi bwakozwe kugeza ubu kuri 7,8-dihydroxyflavones burashimishije, ariko hakenewe ubushakashatsi bwinshi kugira ngo hamenyekane akamaro n'umutekano wa 7,8-dihydroxyflavones kugira ngo ikoreshwe ku bantu. Nyamara, iki kinyabutabire cya flavonoide gifite icyizere gikomeye nk'inyongera mu mirire cyangwa imiti ishobora kuba umuti mu gihe kizaza.
7,8-Dihydroxyflavone ni ikintu karemano, kizwi kandi nka 7,8-DHF, cyakunzwe cyane mu myaka ya vuba aha kubera akamaro kacyo ku buzima bw'abantu.
Iyi mvange isanzwe iri mu muryango wa flavonoid kandi iboneka mu bimera bitandukanye, harimo n'umuzi wa Scutellaria baicalensis.
1. Kunoza imikorere y'ubwonko
Ubushakashatsi bwerekana ko iki kinyabutabire gikora nk'umuti wa TrkB agonist, bivuze ko gikoresha receptor za TrkB mu bwonko. Izi receptor zishinzwe guteza imbere gukura no kubaho kwa neuron, ndetse no kongera ubushobozi bw'ubwonko bwo guhinduka no guhinduka. Mu gukangura receptor za TrkB, byagaragaye ko 7,8-dihydroxyflavone itera imbere kwibuka no gutekereza. Ibi bituma ishobora kuba umuti uvura indwara z'ubwonko nka Alzheimer's disease.
2. Ingaruka zo kurwanya ihungabana
Mu gukora receptors za TrkB, iyi nyunganiramirire itera imbere gukura kwa neuron nshya muri hippocampus, agace k'ubwonko gafite uruhare mu kugenzura amarangamutima. Ubushakashatsi ku nyamaswa bwagaragaje ko 7,8-dihydroxyflavone ishobora kugabanya ibimenyetso byo kwiheba no kongera ubudahangarwa bw'imihangayiko. Ibi byavumbuwe bigaragaza ko iyi nyunganiramirire ishobora gukoreshwa nk'ubundi buryo karemano bwo gusimbura imiti gakondo igabanya ubukana bw'imihangayiko.
3. Imiterere yo kurwanya ububyimbirwe n'ubushobozi bwo kurwanya uburozi
7,8-Dihydroxyflavone ni antioxydant ikomeye ifasha mu kurinda uturemangingo stress ya oxidative iterwa na radicals free. Ubu burinzi bugabanya ibyago byo kurwara indwara zidakira kandi bugatinza gusaza.
Ubuvuzi bw'ubwonko bushobora kugira uruhare mu iterambere no mu iterambere ry'indwara zitandukanye zo mu bwonko, harimo indwara ya Parkinson na sclerosis nyinshi. Ubushakashatsi bwerekana ko 7,8-DHF ifite ubushobozi bwo kurwanya ubuvuzi bufasha kugabanya ubuvuzi mu bwonko no gukumira kwangirika kw'ubwonko. Mu kubuza ikorwa ry'uturemangingo dutuma habaho ubuvuzi, iki kinyabutabire gishobora kugira ubushobozi bwo kugabanya ibimenyetso no kugabanya iterambere ry'izo ndwara zica intege.
4. Ifite ubushobozi bwo kuvura indwara zo guhangayika
Ubushakashatsi ku nyamaswa bwagaragaje ko iki kinyabutabire gishobora kugabanya imyitwarire nk'iy'imihangayiko binyuze mu gukoresha za receptors za TrkB muri amygdala, agace k'ubwonko gafite uruhare mu gutera ubwoba no guhangana n'imihangayiko. Mu guhindura imikorere y'izi receptor, 7,8-dihydroxyflavones zishobora gutanga uburyo busanzwe kandi bwiza bwo gucunga imihangayiko nta ngaruka mbi zijyanye n'imiti gakondo irwanya imihangayiko.
Mbere yo gusuzuma amasoko y'ibiribwa, reka dusobanukirwe icyo 7,8-dihydroxyflavone ari cyo. Ni flavonoid isanzwe iri mu bwoko bwa flavonoid. Flavonoid ni ibikomoka ku bimera bizwiho ubushobozi bwo kurwanya antioxydants, bifasha kurinda uturemangingo kwangiza uturemangingo.
Noneho, reka turebere hamwe ibiryo birimo ingano nyinshi ya 7,8-dihydroxyflavone:
1. Imbuto z'imiti y'indimu
Imwe mu masoko meza ya 7,8-dihydroxyflavones ni imbuto z'indimu nka amacunga, indimu, grapefruit na lime. Izi mbuto ntizikungahaye kuri vitamine C gusa, ahubwo zirimo flavonoids zitandukanye, harimo na 7,8-dihydroxyflavone.
2. Imbuto
Imbuto nk'amabara y'ubururu, amashu, amashu, n'amashu y'ubururu bizwiho kuba bifite antioxydants nyinshi. Izi mbuto ziryoshye kandi ni isoko nziza ya 7,8-dihydroxyflavone, biguha inyungu zikubye kabiri ubuzima.
3. Shokora yijimye
Inkuru nziza ku bakunda shokora! Shokora yijimye, cyane cyane iyo ifite kakao nyinshi, irimo ingano nyinshi ya 7,8-dihydroxyflavonoids. Ariko, hitamo ubwoko bufite isukari nkeya kugira ngo ubone inyungu zose.
4. Icyayi cy'icyatsi kibisi
Uretse kuba ikinyobwa gikunzwe cyane, icyayi kibisi gikungahaye kuri flavonoide, harimo na 7,8-dihydroxyflavone. Kunywa icyayi kibisi buri gihe bishobora gufasha kongera unywa antioxydants no gushyigikira ubuzima bwiza muri rusange.
5. Soya
Niba ushaka isoko y'ibimera ya 7,8-dihydroxyflavone, soya ni amahitamo meza. Ntabwo ari nyinshi muri poroteyine gusa, ahubwo inakubiyemo flavonoide zitandukanye zigira uruhare mu miterere yazo myiza.
6. Imboga z'icyatsi kibisi
Imboga nka kale, epinari, na broccoli ntabwo ari karori nke gusa, ahubwo zinakungahaye kuri antioxydants. Izi mboga z'ibyatsi ni isoko nziza ya 7,8-dihydroxyflavone, ndetse n'izindi ntungamubiri z'ingenzi.
7. Divayi itukura
Muraho! Kunywa divayi itukura mu rugero ruringaniye birimo ubwoko bwa flavonoid yitwa resveratrol, irimo 7,8-dihydroxyflavone. Iyi mvange ifatwa nk'ifite uruhare mu gutuma umutima urushaho kugira ubuzima bwiza bitewe no kunywa divayi itukura mu rugero ruringaniye.
Gushyira ibi biribwa mu mirire yawe bishobora kuguha inyungu nyinshi zijyanye na 7,8-dihydroxyflavone.
7,8-Dihydroxyflavone, izwi kandi nka DHF cyangwa baicalein, ni flavonoide isanzwe iboneka mu bimera bitandukanye, harimo n'umuzi wa Scutellaria baicalensis. Iyi mvange yibanzweho cyane mu myaka ya vuba aha kubera akamaro kayo ku buzima n'imiti ivura. Ariko, iyo urebye umutekano w'ikintu icyo ari cyo cyose, ni ngombwa gusuzuma ibimenyetso bya siyansi biboneka. None se, 7,8-dihydroxyflavone ni nziza?
Ku bijyanye n'umutekano wayo, ubushakashatsi buke bwakozwe ku ikoreshwa ry'umuti wa 7,8-dihydroxyflavone ku bantu. Kubwibyo, gutanga ibitekerezo bifatika ku mutekano wayo biragoye. Ariko, ubushakashatsi ku nyamaswa bwatanze ubumenyi bw'ingirakamaro ku burozi bwayo bushobora kuba. Inyamaswa zitandukanye zagaragaje ko nta ngaruka mbi zikomeye zagaragaye nyuma yo guhabwa DHF, ndetse no ku gipimo kiri hejuru. Ibi bigaragaza ko 7,8-dihydroxyflavone ishobora kwihanganirwa, nibura mu bipimo byakozweho ubushakashatsi.
Ariko, umuntu agomba kwitonda mu gufata imyanzuro ishingiye gusa ku bushakashatsi ku nyamaswa. Ingaruka z'ibintu bishobora gutandukana cyane hagati y'ubwoko, bityo rero, ni ngombwa kwitonda mu gusesengura ibyavuye mu bushakashatsi ku bantu. Byongeye kandi, kuba nta bushakashatsi burambuye bwakozwe ku bantu bwarabujije isuzuma ryumvikana ry'umutekano wabyo.
7,8-Dihydroxyflavone (7,8-DHF) ni flavonoide isanzwe yibanzweho cyane kubera akamaro kayo ku buzima, icyakora, ni ingenzi cyane kumenya ingano n'inama byatanzwe mu gihe ukoresha 7,8-DHF y'ingenzi.
Ni ngombwa kugisha inama abaganga ku bijyanye n'ingano ya 7,8-DHF, kuko ingano ikwiye ishobora gutandukana bitewe n'ibintu byinshi nk'imyaka, ibiro n'indwara runaka. Ubushakashatsi buriho bugaragaza uburyo butandukanye bwo gupima, ubusanzwe 20 kugeza kuri 60 mg ku munsi. Ariko, ni ngombwa kumenya ko izi nama zidashyirwaho kandi zishobora guhinduka uko ibimenyetso byinshi bya siyansi bikusanywa.
Mu gihe uguze inyongeramusaruro za 7,8-DHF, ni ngombwa guhitamo uruganda rwizewe kandi rwizewe kugira ngo rurebe neza umutekano n'ubushobozi bw'umuti. Gusoma ibitekerezo by'abakiriya no kugenzura ibizamini bya laboratwari nabyo bishobora gufasha kumenya ko umuti wizewe. Ni ngombwa cyane gukurikiza inama z'umuganga wawe. Bazashobora gutanga ubuyobozi bwihariye hashingiwe ku mateka y'ubuzima bwawe n'imiterere y'ubuzima bwawe. Buri gihe ni byiza gutangirana n'umuti muto kandi ukongera buhoro buhoro uko bikenewe uyobowe n'umuganga.
Mbere yo gushyira 7,8-DHF mu mikoreshereze yawe ya buri munsi, ni ngombwa kumenya ingaruka mbi zishobora kubaho cyangwa ingaruka mbi ku miti. Nubwo 7,8-DHF muri rusange yihanganirwa neza, hari abantu bashobora kugira ibibazo byoroheje by’igifu cyangwa ingaruka mbi ku barwayi. Nanone, menya neza ko wamenyesheje umuganga wawe imiti cyangwa inyongeramusaruro urimo gufata kugira ngo wirinde ingaruka mbi zishobora kubaho. Wibuke ko gufata inyongeramusaruro iyo ari yo yose bigomba guhora bigenzurwa n’umuganga kugira ngo ubuzima bwawe burusheho kuba bwiza.
Q: Bifata igihe kingana iki kugira ngo 7,8-dihydroxyflavone cyangwa ikore?
A: Umuvuduko 7,8-dihydroxyflavone (7,8-DHF) ikora ushobora gutandukana bitewe n'ibintu byinshi. Mu bushakashatsi bwa siyansi, 7,8-DHF yagaragaje ko igira ingaruka zitandukanye, nko guteza imbere irekurwa ry'ibintu bitera indwara z'ubwonko no kurinda ubwonko. Igihe bifata kugira ngo izi ngaruka zigaragare gishobora kuva ku masaha kugeza ku minsi cyangwa se kirenzeho, bitewe n'uburyo runaka bw'imikorere n'icyo iki kinyabutabire kigamije.
Icyitonderwa: Iyi nkuru ni iy'amakuru gusa kandi ntigomba gufatwa nk'inama z'abaganga. Buri gihe banza uganire n'inzobere mu by'ubuzima mbere yo gukoresha inyongeramusaruro cyangwa guhindura uburyo bwo kwivuza.
Igihe cyo kohereza: Nyakanga-04-2023
