7,8-Dihydroxyflavone ni iki kandi kuki ugomba kubyitaho?

7,8-Dihydroxyflavone (7,8-DHF)ni ibisanzwe bisanzwe flavonoide, ifumbire ya polifenolike iboneka mubihingwa bitandukanye. Flavonoide izwiho kurwanya antioxydants kandi igira uruhare runini muburyo bwo kwirinda ibimera. 7,8-Dihydroxyflavone iboneka cyane mubimera nka Godmania aesculifolia na Tridax procumbens.

7,8-Dihydroxyflavone itandukanye nizindi flavonoide mubushobozi bwayo bwo kwigana ibikorwa byubwonko bukomoka mubwonko (BDNF). BDNF ni poroteyine ishyigikira kubaho, iterambere, n'imikorere ya neuron mu bwonko. Ifite uruhare runini muri neuroplastique, ubushobozi bwubwonko bwo kwisubiraho ubwabwo bukora imiyoboro mishya. Uyu mutungo wa 7,8-DHF ufungura inzira nyinshi zubushakashatsi, cyane cyane mubijyanye na neuroscience.

Uburyo bwibikorwa

Uburyo bwibanze 7,8-Dihydroxyflavone ikoresha ingaruka zayo ni ugukora reseptor ya TrkB (tropomyosin reseptor kinase B). TrkB niyakirwa ryinshi rya BDNF. Iyo 7,8-Dihydroxyflavone ihujwe na TrkB, itera urukurikirane rwinzira zerekana ibimenyetso byerekana ubuzima bwa neuronal kubaho, gukura, no gutandukana.

Ubushakashatsi bwibanze bwerekanye ko 7,8-dihydroxyflavone ishobora kwigana BDNF (ubwonko bukomoka mu bwonko ikomoka mu bwonko) kandi ikongera imvugo n’urwego muri hippocampus. Mubyitegererezo byinyamanswa, ifite ubushobozi bwo kuvura indwara nyinshi zifata ubwonko cyangwa imvururu, arizo stroke, depression, n'indwara ya Parkinson. Mu bushakashatsi bubiri butandukanye, 7,8-dihydroxyflavone yerekanye bioavailable yo mu kanwa kandi wasangaga irenga inzitizi yubwonko bwamaraso (BBB). Kuberako ikora kuri nitric oxyde yerekana inzira kandi ikora reseptor ya TrkB (reseptor tropomyosin reseptor kinase B)

Impamvu ya neurotrophique BDNF itanga cyane cyane ibimenyetso muguhuza reseptors yihariye, bityo bikagira ingaruka kumikorere ya neuron. Mugihe 7,8-DHF ishobora kwigana ingaruka ziterwa na neurotrophique BDNF, urufunguzo ruri muburyo bwimikoranire hamwe na reseptor ya BDNF. Ubushakashatsi bwerekanye ko 7,8-DHF ishobora guhuza reseptor ya BDNF TrkB hanyuma igakora inzira yerekana ibimenyetso byerekana inzira.

By'umwihariko, iyo 7,8-DHF ihujwe na TrkB, itera urukurikirane rw'ibimenyetso byo kwanduza ibimenyetso. Ibi birimo gukora protein kinase nka PI3K / Akt na MAPK / ERK inzira. Gukora izi nzira nibyingenzi mugutezimbere ubuzima bwa neuronal, gukura, hamwe na plastike ya synaptique. Mugereranya imikorere yiyi nzira na BDNF, 7,8-DHF ifasha kuzamura imihindagurikire yimitsi no kurwanya imihangayiko yo hanze.

7,8-DHF igenga kandi imiterere ya gene muri neuron. Irashobora kugira ingaruka ku iyandikwa rya genes zijyanye na neurodevelopment, neuroprotection hamwe na synaps, bityo bigana ingaruka za BDNF kurwego rwa molekile. Ihindurwa ryimvugo ya gene irashigikira kandi uruhare rwa 7,8-DHF mugutezimbere ubuzima bwimitsi.

7,8-Dihydroxyflavone (7,8-DHF) ni flavonoide ya monofenolike ifite ingaruka nyinshi. Ikora nka agonist kuri neurotrophique tyrosine kinase reseptor TrkB (Kd = 320nM) kandi ikingira neuron yerekana TrkB yerekana apoptose. Ubwonko bukomoka mu bwonko bukomoka ku bwonko (BDNF) ni poroteyine ifite ingaruka za neurotrophique zikenewe mu gukora ubwonko, kwiga no kwibuka.

• Neuroprotection: 7,8-DHF ni neuroprotective mubyitegererezo byinyamanswa zindwara ya Parkinson, ishyigikira imyigire yamarangamutima yimbeba kandi igahindura defisite yibuka mubyitegererezo byimbeba zindwara ya Alzheimer, kandi irashobora kandi kunoza imikorere ya moteri no kongera igihe cyo guhiga igihe cyo kubaho kwicyitegererezo cy’inyamaswa zirwaye. BDNF irashobora guteza imbere neuroplastique no kubaho kwa neuron, ifasha ubwonko kubyara imiyoboro mishya mishya, gusana ingirabuzimafatizo zananiranye, no kurinda ingirabuzimafatizo nzima. Ni ngombwa mu gukora ubwonko, kwiga no kwibuka, kandi birashobora kurinda ubwonko ubumuga bwo kutamenya. Kugabanuka mubushobozi bwubwenge kandi wirinde indwara zifata ubwonko nkindwara ya Alzheimer nindwara ya Parkinson.

• Igenga ubuzima bwa neuronal: 7,8-DHF irashobora guhuza na TrkB kandi igakora inzira yerekana ibimenyetso byerekana inzira, nka PI3K / Akt na MAPK / ERK inzira. Gukora kwinzira ninzira zingenzi mugutezimbere ubuzima bwa neuronal, gukura hamwe na plastike ya synaptic. ngombwa. BDNF nayo ni neurotrophique ishobora gukora inzira yerekana ibimenyetso byerekana inzira ihuza reseptor ya TrkB kandi igateza imbere kubaho no gukura kwa neuron.

• Gutezimbere plastike ya synaptique: 7,8-DHF irashobora guteza imbere gushiraho no gushimangira synaps ukoresheje reseptor ya TrkB, bityo bikazamura imikorere yo kwanduza synaptic. BDNF nayo yatekerejweho guteza imbere ishingwa no gushimangira synaps, bityo bikongerera ubushobozi bwo kwanduza synaptic bityo bikazamura ubushobozi bwo kwiga no kwibuka.

• Ingaruka zo kwiga no kwibuka: 7,8-DHF irashobora kunoza imyigire nubushobozi bwo kwibuka mumbeba, bishobora kuba bifitanye isano n'ingaruka zabyo mubuzima bwa neuronal na plastique synaptic. BDNF igira kandi uruhare runini mukwiga no kwibuka mugutezimbere kubaho kwa neuron no gushiraho synaps, bityo bikazamura ubushobozi bwo kwiga no kwibuka.

• Ihindura imyifatire: 7,8-DHF ifite ingaruka zo guhindura imyumvire, ishobora kuba ifitanye isano n'ingaruka zayo mubuzima bwa neuronal na plastique synaptic. BDNF nayo itekereza ko igira uruhare mukugenzura amarangamutima mugutegeka kubaho kwa neuron no gushiraho synaps, bityo bikagira ingaruka kumagambo.

Muri make, 7,8-DHF na BDNF bafite uburyo bumwe bwibikorwa muri neuroprotection, kugenzura ubuzima bwa neuronal, guteza imbere plastike ya synaptique, bigira ingaruka kumyigire no kwibuka, no kugenzura amarangamutima.

Suzhou Myland Pharm & Nutrition Inc ni uruganda rwanditswe na FDA rutanga ubuziranenge kandi bwera cyane 7,8-Dihydroxyflavone.

Muri Pharm ya Suzhou Myland twiyemeje gutanga ibicuruzwa byiza cyane kubiciro byiza. 7,8-Dihydroxyflavone yacu irageragezwa cyane kugirango isukure nimbaraga, ikwemeza ko uzabona inyongera yujuje ubuziranenge ushobora kwizera. Waba ushaka gushyigikira ubuzima bwa selile, kuzamura sisitemu yumubiri cyangwa kuzamura ubuzima muri rusange, 7,8-Dihydroxyflavone yacu ni amahitamo meza.

Hamwe nuburambe bwimyaka 30 kandi itwarwa nubuhanga buhanitse hamwe nuburyo bunoze bwa R&D, Pharm ya Suzhou Myland Pharm yateje imbere ibicuruzwa bitandukanye byapiganiwe kandi ihinduka ubuzima bushya bwa siyanse yubuzima, synthèse progaramu na sosiyete ikora serivise.

Mubyongeyeho, Suzhou Myland Pharm nayo ikora FDA yemewe. Ibikoresho bya sosiyete R&D, ibikoresho byo kubyaza umusaruro, nibikoresho byisesengura nibigezweho kandi byinshi, kandi birashobora gukora imiti kuva kuri miligarama kugeza kuri toni mubipimo, kandi ikubahiriza ibipimo bya ISO 9001 nibisobanuro bya GMP.