7,8-Dihydroxyflavone ni iki kandi kuki ukwiye kuyitaho?

7,8-Dihydroxyflavone (7,8-DHF)ni flavonoide isanzwe, imvange ya polyphenolic iboneka mu bimera bitandukanye. Flavonoide zizwiho ubushobozi bwazo bwo kurwanya antioxidant kandi zigira uruhare runini mu mikorere yo kwirinda ibimera. 7,8-Dihydroxyflavone iboneka cyane cyane mu bimera nka Godmania aesculifolia na Tridax procumbens.

7,8-Dihydroxyflavone itandukanye n'izindi flavonoide mu bushobozi bwayo bwo kwigana imikorere y'ubwonko bukomoka ku miterere y'ubwonko (BDNF). BDNF ni poroteyine ishyigikira kubaho, iterambere, n'imikorere y'imitsi mu bwonko. Igira uruhare runini mu gutuma ubwonko burushaho kwiyubaka binyuze mu gukora imiyoboro mishya y'imitsi. Iyi miterere ya 7,8-DHF ifungura inzira nyinshi z'ubushakashatsi, cyane cyane mu bijyanye n'imitsi.

Uburyo bw'ibikorwa

Uburyo bw'ibanze 7,8-Dihydroxyflavone ikoresha mu gutanga ingaruka zayo ni ugukora kwa receptor ya TrkB (tropomyosin receptor kinase B). TrkB ni receptor ifite ubwisungane bwinshi kuri BDNF. Iyo 7,8-Dihydroxyflavone yifatanye na TrkB, itera urukurikirane rw'inzira zo mu ngirabuzimafatizo zituma imikorere y'imitsi ikomeza kubaho, ikura, kandi igatandukanya.

Ubushakashatsi bwakozwe mbere y’uko ubuvuzi butangira bwagaragaje ko 7,8-dihydroxyflavone ishobora kwigana BDNF (neurotrophic factor ikomoka ku bwonko) no kongera imiterere yayo n’urwego rwayo muri hippocampus. Mu nyamaswa, ifite ubushobozi bwo kuvura indwara nyinshi zo mu bwonko cyangwa indwara zo mu bwonko, ari zo stroke, kwiheba, n’indwara ya Parkinson. Mu bushakashatsi bubiri butandukanye, 7,8-dihydroxyflavone yagaragaje ko iboneka cyane mu kanwa kandi byagaragaye ko yambukiranya umupaka w’ubwonko n’amaraso (BBB). Kubera ko ikora ku nzira y’ibimenyetso bya nitric oxide na receptor ya TrkB (tropomyosin receptor kinase B)

Igipimo cy’imitsi BDNF cyohereza ibimenyetso ahanini binyuze mu gufatana na za receptor runaka, bityo bigira ingaruka ku mikorere y’uturemangingo tw’imitsi. Nubwo 7,8-DHF ishobora kwigana ingaruka za factor ya neurotrophic BDNF, ikintu cy’ingenzi kiri mu buryo ikorana na receptor ya BDNF. Ubushakashatsi bwagaragaje ko 7,8-DHF ishobora gufatana na receptor ya BDNF TrkB no gukora inzira zo mu nzira zo hasi.

By’umwihariko, iyo 7,8-DHF ifatanye na TrkB, itera urukurikirane rw’ibikorwa byo kohereza ibimenyetso mu ngirabuzimafatizo. Ibi birimo gukora poroteyine kinase nka PI3K/Akt na MAPK/ERK pathways. Gukora imikorere y’izi nzira ni ingenzi mu guteza imbere kubaho kw’imitsi, gukura, no gukora neza kw’imitsi. Mu kwigana gukora kw’izi nzira na BDNF, 7,8-DHF ifasha kongera ubushobozi bwo guhuza imitsi no kurwanya stress zo hanze.

7,8-DHF inagenzura igaragara ry'uturemangingo mu mitsi. Ishobora kugira ingaruka ku ihindurwa ry'uturemangingo dufitanye isano n'iterambere ry'ubwonko, uburinzi bw'ubwonko n'ikorwa rya sinapse, bityo ikigana ingaruka za BDNF ku rwego rwa molekile. Uku guhindura igaragara ry'uturemangingo bishyigikira uruhare rwa 7,8-DHF mu guteza imbere ubuzima bw'ubwonko.

7,8-Dihydroxyflavone (7,8-DHF) ni flavonoid imwe ifite ingaruka nyinshi. Ikora nk'umusemburo wa receptor ya neurotrophic tyrosine kinase TrkB (Kd=320nM) kandi ikarinda neurons zigaragaza TrkB kwandura apoptosis. Brain-derived neurotrophic factor (BDNF) ni poroteyine ifite ingaruka za neurotrophic zikenewe cyane mu miterere y'ubwonko, kwiga no kwibuka.

• Uburinzi bw'ubwonko: 7,8-DHF irinda ubwonko mu nyamaswa zirwaye indwara ya Parkinson, ishyigikira kwiga amarangamutima mu mbeba kandi igakuraho ikibazo cyo kwibuka mu mbeba zirwaye indwara ya Alzheimer, kandi ishobora no kunoza imikorere y'imitsi no kongera igihe cyo kubaho kw'inyamaswa zirwaye. BDNF ishobora kunoza uburyo bwo kuvura ubwonko no kubaho kw'imitsi, igafasha ubwonko gukora imiyoboro mishya y'ubwonko, gusana uturemangingo tw'ubwonko twangiritse, no kurinda uturemangingo tw'ubwonko tuzima. Ni ingenzi mu miterere y'ubwonko, kwiga no kwibuka, kandi ishobora kurinda ubwonko ubumuga bwo mu mutwe buterwa n'izabukuru. Igabanya ubushobozi bwo gutekereza no kurinda indwara z'ubwonko nka Alzheimer na Parkinson.

• Igenzura ubuzima bw'imitsi: 7,8-DHF ishobora gufatana na TrkB no gukora inzira zo gusimbuza amakuru zo mu gice cyo hepfo, nka PI3K/Akt na MAPK/ERK. Gukorana kw'izi nzira ni ingenzi cyane mu guteza imbere ubuzima bw'imitsi, gukura no gukwirakwira kw'imitsi mu buryo bwa synaptic. BDNF kandi ni ikintu cy'imitsi gishobora gukorana inzira zo gusimbuza amakuru mu ngirabuzimafatizo binyuze mu gufatana na za receptors za TrkB no guteza imbere ubuzima no gukura kw'imitsi.

• Guteza imbere uburyo synapse ikora: 7,8-DHF ishobora guteza imbere ishingwa n’ishimangirwa rya synapse binyuze mu gukora receptors za TrkB, bityo bikanoza imikorere y’ishingwa rya synapse. BDNF ifatwa kandi nk’itera imbere ishingwa n’ishimangirwa rya synapse, bityo ikongera imikorere y’ishingwa rya synapse bityo ikongera ubushobozi bwo kwiga no kwibuka.

• Ingaruka ku myigire no kwibuka: 7,8-DHF ishobora kunoza ubushobozi bwo kwiga no kwibuka mu mbeba, ibi bikaba bishobora kuba bifitanye isano n’ingaruka zayo ku kubaho kw’imitsi no ku buryo ingirabuzimafatizo zikora neza. BDNF kandi igira uruhare runini mu myigire no kwibuka binyuze mu guteza imbere ubuzima bw’imitsi no gushinga amashami ya sinapse, bityo ikanoza ubushobozi bwo kwiga no kwibuka.

• Ihindura ibyiyumvo: 7,8-DHF ifite ingaruka zo guhindura ibyiyumvo, zishobora kuba zifitanye isano n'ingaruka zayo ku kubaho kw'imitsi no ku buryo ikora neza mu mikorere y'imitsi. BDNF ifatwa kandi nk'igira uruhare mu kugenzura amarangamutima binyuze mu kugenzura kubaho kw'imitsi no gushinga imitsi, bityo ikagira ingaruka ku kugaragaza amarangamutima.

Muri make, 7,8-DHF na BDNF bifite uburyo bumwe bwo gukora mu kurinda ubwonko, bigenzura ubuzima bw'imitsi, biteza imbere uburyo bwo guhuza imikorere y'uturemangingo, bigira ingaruka ku myigire no kwibuka, kandi bigenzura amarangamutima.

Suzhou Myland Pharm & Nutrition Inc. ni uruganda rwemewe na FDA rutanga 7,8-Dihydroxyflavone nziza kandi isukuye cyane.

Muri Suzhou Myland Pharm twiyemeje gutanga ibicuruzwa byiza cyane ku giciro cyiza. 7,8-Dihydroxyflavone yacu irageragezwa cyane kugira ngo imenyekane ko ifite isuku kandi ikomeye, bityo ikaguha inyunganizi nziza ushobora kwizera. Waba ushaka gufasha ubuzima bw'uturemangingo, kongera ubudahangarwa bw'umubiri wawe cyangwa kongera ubuzima bwiza muri rusange, 7,8-Dihydroxyflavone yacu ni yo mahitamo meza.

Suzhou Myland Pharm ifite uburambe bw'imyaka 30 kandi iyobowe n'ikoranabuhanga rigezweho hamwe n'ingamba zo gukora ubushakashatsi n'iterambere zinoze cyane, yateje imbere ibicuruzwa bitandukanye kandi iba ikigo gishya gitanga serivisi z'inyongera ku buzima, gukora ibintu bitandukanye no gukora ibikoresho bitandukanye.

Byongeye kandi, Suzhou Myland Pharm ni uruganda rwanditswe na FDA. Imbuga z’ubushakashatsi n’iterambere by’iyi sosiyete, ibikoresho byayo byo gukora, n’ibikoresho byo gusesengura ni ibintu bigezweho kandi bifite imikorere myinshi, kandi bishobora gukora imiti kuva kuri miligarama kugeza kuri toni, kandi bikurikiza amahame ya ISO 9001 n’ibipimo bya GMP mu gukora.