1-Methylnicotinamide Chloride CAS No.:1005-24-9
Ibipimo by'ibicuruzwa
| Izina ry'igicuruzwa | 1-Methylnicotinamide chloride |
| Irindi zina | Chloride ya N-Methylnicotinamide ； NMN-Cl ； Chloride ya 1-MNA；3-carbamoyl-1-methyl-pyridinium chloride |
| Nimero ya CAS | 1005-24-9 |
| Ifishi y'ingirabuzimafatizo | C7H9N2OCl |
| Uburemere bwa molekile | 172.61 |
| Ubwiza | 98.5% |
| Isura | Umweru - nta wera cyane, ufite kristali ikomeyeifu |
| Gupakira | 1kg/umufuka; 25kg/ingoma |
| Porogaramu | cubuvuzi bw'umubirieigeragezamikirere |
Intangiriro y'ibicuruzwa
1-Methylnicotinamide chloride ni methylated derivative ya nicotinamide, irangwa n'imiterere ihamye ya quaternary ammonium salt. Ikora nk'igice cy'ingenzi mu kwiga metabolism ya nicotinamide. Uburyo bwiza bwo gushonga mu mazi no kudahindagurika mu mikorere y'imiti bituma ikoreshwa nk'igikoresho cy'ubushakashatsi ku binyabuzima.
1-MNA ni ikintu gisanzwe kiba mu mubiri w'umuntu, gikora nk'umusaruro usanzwe w'imikorere ya niacin. Nk'igice cy'ingenzi muri iyi nzira ya metabolism, 1-MNA yongera gutunganywa na aldehyde oxidase kugira ngo ikore metabolites zo mu gice cy'imbere nka N-methyl-2-pyridone-5-carboxamide (2PY) na N-methyl-4-pyridone-3-carboxamide (4PY), amaherezo zigasohoka mu nkari.
1-Methylnicotinamide chloride ni methylated derivative ya nicotinamide, irangwa n'imiterere ihamye ya quaternary ammonium salt. Ikora nk'igice cy'ingenzi mu kwiga metabolism ya nicotinamide. Uburyo bwiza bwo gushonga mu mazi no kudahindagurika mu mikorere y'imiti bituma ikoreshwa nk'igikoresho cy'ubushakashatsi ku binyabuzima.
1-MNA ni ikintu gisanzwe kiba mu mubiri w'umuntu, gikora nk'umusaruro usanzwe w'imikorere ya niacin. Nk'igice cy'ingenzi muri iyi nzira ya metabolism, 1-MNA yongera gutunganywa na aldehyde oxidase kugira ngo ikore metabolites zo mu gice cy'imbere nka N-methyl-2-pyridone-5-carboxamide (2PY) na N-methyl-4-pyridone-3-carboxamide (4PY), amaherezo zigasohoka mu nkari.
Ikiranga
(1) Gushonga kw'amazi: Bishobora gushonga byoroshye mu mazi no mu bintu bishongesha ibidukikije.
(2) Gutuza: Bihamye mu gihe cy'ubushyuhe bw'icyumba ariko bisaba kubikwa ahantu hadashobora gushuha.
(3) Umutekano: Umuryango w’Ubumwe bw’u Burayi wakoze isuzuma rya siyansi rya 1-MNA nk'ikintu gishya kiri mu biribwa. Dukurikije amabwiriza y’Umuryango w’Ubumwe bw’u Burayi (EC) No 258/97, 1-MNA ifatwa nk'aho ari nziza ku muntu urya, aho umuntu mukuru asabwa kurya 58 mg ku munsi, ahanini igenewe gukoreshwa mu nyongeramusaruro z’ibiribwa.
Porogaramu
1-Methylnicotinamide chloride (MNC) ni methylated derivative ya nicotinamide. Gupima 1-MNA bishobora gukorwa hakoreshejwe uburyo nka high-performance liquid chromatography (HPLC) na enzyme-linked immunosorbent assay (ELISA). Igaragaza ubushobozi bwo gukoreshwa mu biribwa n'ibikomoka ku buzima. Mu nganda z'ibiribwa, ishobora gukora nk'ingufu zirwanya oxidation kugira ngo itinde oxidation y'ibinure no kubungabunga ubuziranenge bw'ibiribwa. Bitewe n'imiterere yayo, ishobora no kuba ikintu cy'ingenzi mu biribwa bikungahaye ku ntungamubiri. Byongeye kandi, 1-MNA igaragaza ibikorwa mu kugenzura imikorere y'umubiri no kunoza imiterere y'umubiri, ikayiha agaciro mu iterambere ry'ibiribwa bikora neza n'inyongeramusaruro zikomoka ku ntungamubiri.
Isuzuma ryakozwe n’Umuryango w’Ubumwe bw’u Burayi ryagaragaje ko kurya buri munsi miligarama 58 za 1-MNA bivuye mu nyongeramusaruro z’ibiribwa bidashoboka ko byagira ingaruka mbi ku buzima bw’abantu, kandi byashyizwe ku mugaragaro mu rutonde rw’ibiribwa bishya by’Umuryango w’Ubumwe bw’u Burayi.
Nk’uko ari molekile ikomeye ikora ku buzima n’amahame ngenderwaho, 1-methylnicotinamide chloride ifite amahirwe menshi yo gukoreshwa mu bushakashatsi bwa siyansi, mu iterambere ry’imiti, no mu nganda z’inyongeramusaruro z’ibiribwa. Isuzumabumenyi ryayo ry’umutekano risobanutse neza n’ibikorwa bitandukanye by’ibinyabuzima bigaragaza ko ari ingingo y’ingenzi mu bushakashatsi no mu bikorwa bitandukanye.
