Uruganda rukora ifu ya Agomelatine CAS No.: 138112-76-2 99% isuku min. kubintu byongeweho
Video y'ibicuruzwa
Ibipimo byibicuruzwa
| Izina ryibicuruzwa | Agomelatine |
| Irindi zina | N- [2- (7-Methoxy-1-naphthyl) ethyl] acetamide; N- [2- |
| URUBANZA No. | 138112-76-2 |
| Inzira ya molekulari | C15H17NO2 |
| Uburemere bwa molekile | 243.3082 |
| Isuku | 99.0% |
| Kugaragara | Ifu yera |
| Gupakira | 1kg / umufuka 25kg / ingoma |
| Gusaba | Ibicuruzwa byubuzima ibikoresho fatizo |
Kumenyekanisha ibicuruzwa
Agomelatine yatangijwe bwa mbere mu Burayi mu 2009 none yemerewe gukoreshwa mu bihugu birenga 70. Bitandukanye na antidepressants gakondo, agomelatine ikora yibasira melatonine na serotonine yakira mubwonko. Mugukora nka agonist kuri reseptor ya melatonin, agomelatine ifasha muburyo bwo gusinzira bwahungabanye akenshi bijyana no kwiheba. Ubu buryo ntabwo bufasha gusa kunoza ibitotsi ahubwo binafasha kugarura injyana ya circadian naturel. Byongeye kandi, agomelatine ikora nka antagonist kuri reseptor zimwe na zimwe (reseptor 5-HT2C). Iki gikorwa kidasanzwe cyibintu byongera mu buryo butaziguye kuboneka kwa serotonine mu bwonko, neurotransmitter ishinzwe kugenzura imiterere. Mugutegeka urwego rwa serotonine, agomelatine irashobora gukora nka antidepressant nziza, igabanya ibimenyetso nkumubabaro, gutakaza inyungu, kumva ufite umutimanama cyangwa agaciro. Byongeye kandi, agomelatine irashobora gutanga izindi nyungu. Ubushakashatsi bwerekana ko bushobora gufasha kunoza imikorere yubwenge Ubushakashatsi bwerekana ubushobozi bwabwo bwo kongera kwibuka, kwitabwaho, hamwe ninshingano nyobozi, bikabera ahantu hashimishije kubushakashatsi buzaza.
Ikiranga
(1) Isuku ryinshi: Agomelatine irashobora kubona ibicuruzwa bifite isuku nyinshi binyuze mu gutunganya umusaruro. Isuku ryinshi risobanura bioavailable nziza hamwe na reaction nkeya.
(2) Umutekano: Umutekano mwinshi, reaction nkeya.
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Porogaramu
Agomelatine ni antidepressant na antagonist ya melatonin. Igabanya ibimenyetso byo kwiheba muguhindura reseptor ya melatonin MT1 (igabanya ibimenyetso byerekana ibimenyetso bya cortical) hamwe na MT2 yakira (injyana yo gusinzira ya circadian) hamwe na serotonine. Ifashwe nijoro, yigana injyana karemano yo gusohora melatonine kandi irashobora kuzamura cyane ibitotsi. Uburyo bwibikorwa byacitse muri sisitemu gakondo ya monoamine. Ikora reseptor ya melatonin MT1 na MT2 kandi irwanya reseptor 5-HT2C. Kunoza ireme ryibitotsi, kugarura injyana yibinyabuzima, kandi bigira ingaruka mbi; muribo, mukurwanya reseptor 5-HT2C kuri membrane ya postynaptic, irashobora kongera irekurwa rya DA na NE muri cortex ibanza, bikagira ingaruka mbi. Iyo MT agonism na 5-HT2C yakira reseptor antagonism ibanye, hashobora kubaho ingaruka zidasanzwe zo guhuza imbaraga, bigateza imbere irekurwa rya DA na NE byinshi mubice byubwonko bwa PFC, bikarushaho gushimangira ingaruka zo kurwanya antidepressant. Byongeye kandi, agomelatine irashobora guteza imbere irekurwa ryubwonko bukomoka mu bwonko bukomoka muri neurone muri PFC kandi bikabuza irekurwa ryatewe na glutamate mu bwonko bwa amygdala.
