Uruganda rukora ifu ya Agomelatine CAS No.: 138112-76-2 99% isuku min.kubintu byongeweho

Agomelatine ni ubwoko bushya bwa antidepressant.Uburyo bwibikorwa byacitse muri sisitemu gakondo ya monoamine.Ikora reseptor ya melatonin, MT1 na MT2, kandi irwanya 5-HT2C.Irashobora kunoza ibitotsi no kugarura injyana ya biologiya mugihe igira ingaruka mbi;muribo, mukurwanya reseptor ya 5-HT2C ya membrane ya postynaptic, irashobora kongera irekurwa rya DA na NE muri cortex ibanza kandi ikagira uruhare mukurwanya antidepressant.Iyo MT agonism na 5-HT2C reseptor antagonism ibaho icyarimwe, hashobora gukorwa ingaruka zidasanzwe zo guhuza imbaraga kugirango habeho irekurwa rya DA na NE nyinshi mubice byubwonko bwa PFC, bikarushaho gushimangira ingaruka zo kurwanya antidepressant.Byongeye kandi, agomelatine irashobora kandi guteza imbere irekurwa ryubwonko bukomoka mu bwonko bukomoka muri ubwonko muri PFC no guhagarika irekurwa ryatewe na glutamate mu bwonko bwa amygdala.