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Ifu ya Agomelatine Nomero ya CAS: 138112-76-2 Isuku 99% ku bikoresho by'inyongera Ishusho yagaragaye
  • Ifu ya Agomelatine Nomero ya CAS: 138112-76-2 Isuku ya 99% ku bikoresho by'inyongera
  • Ifu ya Agomelatine Nomero ya CAS: 138112-76-2 Isuku ya 99% ku bikoresho by'inyongera
  • Ifu ya Agomelatine Nomero ya CAS: 138112-76-2 Isuku ya 99% ku bikoresho by'inyongera
  • Ifu ya Agomelatine Nomero ya CAS: 138112-76-2 Isuku ya 99% ku bikoresho by'inyongera
  • Ifu ya Agomelatine Nomero ya CAS: 138112-76-2 Isuku ya 99% ku bikoresho by'inyongera
  • Ifu ya Agomelatine Nomero ya CAS: 138112-76-2 Isuku ya 99% ku bikoresho by'inyongera

Ifu ya Agomelatine Nomero ya CAS: 138112-76-2 Isuku ya 99% ku bikoresho by'inyongera

Ibisobanuro bigufi:

Agomelatine ni ubwoko bushya bw'umuti ugabanya ubukana bw'indwara. Uburyo ikora bunyura muri sisitemu isanzwe yo kohereza monoamine.


Ibisobanuro birambuye ku gicuruzwa

Ibirango by'ibicuruzwa

Videwo y'ibicuruzwa

Ibipimo by'ibicuruzwa

Izina ry'igicuruzwa

Agomelatine

Irindi zina

N-[2-(7-Methoxy-1-naphthyl)ethyl]acetamide;N-[2-(7methoxynaphthalene-1-yl)ethyl]acetamide

Nimero ya CAS

138112-76-2

Ifishi y'ingirabuzimafatizo

C15H17NO2

Uburemere bwa molekile

243.3082

Ubwiza

99.0%

Isura

Ifu y'umweru

Gupakira

1kg/umufuka 25kg/ingoma

Porogaramu

Ibikoresho fatizo by'ubuzima

Intangiriro y'ibicuruzwa

Agomelatine yatangijwe bwa mbere mu Burayi mu 2009, ubu yemerewe gukoreshwa mu bihugu birenga 70. Bitandukanye n'imiti gakondo yo kurwanya indwara ziterwa n'imiti i ...

Ikiranga

(1) Ubuziranenge bwinshi: Agomelatine ishobora kubona ibicuruzwa bifite ubuziranenge bwinshi binyuze mu gutunganya umusaruro. Ubuziranenge bwinshi busobanura ko binyabuzima biboneka neza kandi ingaruka mbi zikaba nke.

(2) Umutekano: Umutekano mwinshi, ingaruka mbi nke.

(3) Gutuza: Agomelatine ifite ubutuza bwiza kandi ishobora gukomeza imikorere yayo n'ingaruka zayo mu bidukikije bitandukanye no mu buryo butandukanye bwo kubika.

Porogaramu

Agomelatine ni umuti ugabanya ubukana bw'indwara zo mu mutwe (antidepressant) kandi ni umuti urwanya melatonin. Igabanya ibimenyetso byo kwiheba binyuze mu kugenzura receptor za melatonin MT1 (igabanya ibimenyetso by'ihungabana ry'umutima) na receptor za MT2 (circadian sleep rhythm) na serotonin. Iyo ifashwe nijoro, yigana rhythm karemano yo kurekura melatonin kandi ishobora kunoza cyane ubwiza bw'ibitotsi. Uburyo ikora buca muri sisitemu isanzwe ya monoamine transmitter. Ikora receptor za melatonin MT1 na MT2 kandi ikarwanya receptor za 5-HT2C. Yongera ubuziranenge bw'ibitotsi, igasubizaho rhythm y'ibinyabuzima, kandi ikagira ingaruka ku ndwara zo kwiheba; muri zo, binyuze mu kurwanya receptor za 5-HT2C ku ruhu rw'inyuma, ishobora kongera kurekura DA na NE mu gice cy'imbere cy'umutima, ikagira ingaruka ku ndwara zo kwiheba. Iyo MT agonism n'indwano za receptor za 5-HT2C zibaye hamwe, ingaruka zidasanzwe zishobora gukorwa, zigatuma DA na NE byinshi birekurwa mu bwonko bwa PFC, bigakomeza imbaraga z'indwara zo kwiheba. Byongeye kandi, agomelatine ishobora gutuma habaho irekurwa ry’ibintu bikomoka ku bwonko muri PFC no kubuza irekurwa rya glutamate riterwa n’stress mu gace k’ubwonko ka amygdala.

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