Uruganda rukora ifu ya CMS121 CAS No.: 1353224-53-9 98.0% isuku min. kubintu byongeweho
Ibipimo byibicuruzwa
| Izina ryibicuruzwa | CMS121 |
| Irindi zina | CMS-121; 1,2-Benzenediol, 4- [4- (cyclopentyloxy) -2-quinolinyl] -; 4- (4- (cyclopentyloxy) quinolin-2-yl) benzene-1,2-diol (CMS121); ACC, AcetylCoenzymeACarboxylase, indwara, neuroprotective, inhibit, anti-inflammatory, mitochondrial, Alzheimer's, antioxidative, acetylation, Inhibitor, H3K9, Acetyl-CoACarboxylase, CMS121, guta umutwe, ACC1, CMS-121 |
| URUBANZA No. | 1353224-53-9 |
| Inzira ya molekulari | C20H19NO3 |
| Uburemere bwa molekile | 321.37 |
| Isuku | 98.0% |
| Kugaragara | Ifu yumuhondo yoroheje |
| Gusaba | Ibyokurya byongera ibiryo |
Kumenyekanisha ibicuruzwa
4- (4- (cyclopentyloxy) quinolin-2-yl) benzene-1,2-diol ni uruganda rwitwa CMS121. Urwego rwimiterere rugoye rwerekana ko rushobora kuba rufite imiterere yihariye nogukoresha. Kugira ngo wumve akamaro kayo, bifasha kumenya amatsinda yimikorere ihari no gusesengura ingaruka zishobora kubaho. Kuba impeta ya quinoline yerekana ko uruganda rushobora gukora mubuzima. Molekile ikomoka kuri Quinoline izwiho imiterere itandukanye y'ibinyabuzima, harimo ibikorwa bya antibacterial na anti-inflammatory. Umugereka witsinda rya cyclopentyloxy urashobora kugira uruhare mugukemuka kwikigo cyangwa kuzamura ibikorwa byibinyabuzima binyuze mu ngaruka zidasanzwe. Mu bushakashatsi bwakozwe kuri selile HT22, CMS-121 yerekanye ingaruka zikomeye za neuroprotective, zirinda neza izo selile ischemia no kwangirika kwa okiside. Byongeye kandi, CMS-121 ifite ibintu byingenzi birwanya inflammatory, byerekana ubushobozi bwayo bwo guhindura ibisubizo byumuriro. Kubikora, CMS-121 ifite ubushobozi bwo kugabanya gucana mumyanya ningingo zitandukanye. CMS-121 ifite ibikorwa bikomeye bya farumasi nkibuza acetyl-CoA carboxylase 1 (ACC1). Ingaruka zikomeye zo kubuza ACC1 gukora ibice bitanga icyizere.
Ikiranga
(1) Isuku ryinshi: CMS-121 irashobora kubona ibicuruzwa byera cyane binyuze mubikorwa bitunganijwe neza. Isuku ryinshi risobanura bioavailable nziza hamwe na reaction nkeya.
(2) Umutekano: Umutekano mwinshi, reaction nkeya.
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Porogaramu
CMS-121 ni inkomoko ya quinolone kandi ikora mu kanwa acetyl-CoA carboxylase 1 (ACC1) inhibitor ifite imiti itanga imiti. Hakozwe ubushakashatsi bwimbitse kugira ngo hakorwe ubushakashatsi ku nyungu zishobora guterwa na CMS-121 mu bice bitandukanye, birimo neuroprotection, ingaruka zo kurwanya inflammatory, ibikorwa bya antioxydeant, n'ingaruka zabyo ku bimenyetso bifitanye isano no gusaza neza.
