Lemairamin (WGX-50) uruganda rukora ifu CAS No.: 29946-61-0 98.0% isuku min.kubintu byongeweho
Ibipimo byibicuruzwa
| Izina RY'IGICURUZWA | Lemairamin |
| Irindi zina | 2-Propenamide, N- [2- (3,4-dimethoxyphenyl) ethyl] -3-fenyl-, (2E) -; Lemairamin (WGX-50) |
| URUBANZA No. | 29946-61-0 |
| Inzira ya molekulari | C19H21NO3 |
| Uburemere bwa molekile | 311.37 |
| Isuku | 98.0% |
| Kugaragara | Ifu yera-yera |
| Gusaba | Ibyokurya byongera ibiryo |
Kumenyekanisha ibicuruzwa
Lemairamin cyangwa Wgx50 ni ikomatanyirizo risanzwe ryakuwe muri pisine ya chili ryerekanye ibisubizo bitanga umusaruro mukurinda indwara ya Alzheimer.Ubushakashatsi bwerekanye ko bushobora kubuza Aβ iterwa na neuronal apoptose, kugabanya ubumara bwa calcium ya neuronal, no kugabanya kwirundanya kwa Aβ oligomers mu bwonko bwubwonko.Byongeye kandi, wgx50 yerekanwe kunoza imikorere yubwenge mu mbeba.Ubushakashatsi bwerekana ko wgx50 ifite ubushobozi bwo gukumira intungamubiri za poroteyine hagati ya molekile ya amyloide.Muri rusange, wgx50 ifite ubushobozi bwo gukumira indwara ya Alzheimer kandi irashobora gutanga inzira nshya zo guteza imbere imiti yibasira Aβ oligomers.Byongeye kandi, WGX-50 yerekana ibikorwa bikomeye byo kurwanya inflammatory, bigatuma iba umukandida utanga ikizere cyo kuvura indwara zanduza.WGX-50 byagaragaye ko igira ingaruka zikomeye kuruhu, nko kugabanya iminkanyari no kunoza uruhu rworoshye.Usibye ibimera bisanzwe byakuwe mu gihingwa Zanthoxylum bungeanum, kuri ubu hari byinshi byunganirangingo bikoreshwa mubikorwa bitandukanye kandi bikwiriye isoko.
Ikiranga
(1) Isuku ryinshi: Lemairamin irashobora kubona ibicuruzwa byera cyane binyuze mu kuvoma no gutunganya umusaruro.Isuku ryinshi risobanura bioavailable nziza hamwe na reaction nkeya.
(2) Umutekano: Umutekano mwinshi, reaction nkeya, nta reaction mbi igaragara niyo ikoreshwa igihe kirekire.
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(4) Biroroshye kubyakira: Lemairamin irashobora kwinjizwa vuba numubiri wumuntu hanyuma igakwirakwizwa mubice bitandukanye.
Porogaramu
Lemairamin ni uruganda rwa amide rwakuwe mu kibabi cya Zanthoxylum bungeanum.Kugeza ubu ikoreshwa nk'inyongera y'ibiryo, ikora kandi nka agoniste ya alpha7 nicotinic acetylcholine reseptor (α7nAChR), igabanya neuroinflammation mu ndwara ya Alzheimer, kandi ikaba ikora neza. Wgx50 yerekanye ibisubizo bishimishije mubushakashatsi bwibanze, harimo no kubuza Aβ iterwa na neuronal apoptose, kugabanya ubumara bwa calcium ya neuronal calcium, kugabanya kwirundanya kwa Aβ oligomers mumyanya yubwonko, no kunoza imikorere yubwenge mumbeba.
