Ifu ya Lemairamin (WGX-50) nimero ya CAS: 29946-61-0 Isuku ya 98.0% ku bikoresho by'inyongera Ishusho yagaragaye

Ifu ya Lemairamin (WGX-50) nimero ya CAS: 29946-61-0 98.0% by'ubuziranenge bw'ibicuruzwa by'inyongera

Ibisobanuro bigufi:

Lemairamin cyangwa Wgx50 ni ikintu karemano gikomoka kuri chili peppers cyagaragaje umusaruro mwiza mu gukumira indwara ya Alzheimer. Ubushakashatsi bwagaragaje ko gishobora gukumira apoptosis y’imitsi y’ubwonko iterwa na Aβ, kugabanya uburozi bwa calcium mu mitsi y’ubwonko, no kugabanya kwirundanya kwa oligomer za Aβ mu gice cy’ubwonko.

Ohereza imeri kuri twe

Ibisobanuro birambuye ku gicuruzwa

Ibirango by'ibicuruzwa

Videwo y'ibicuruzwa

Ibipimo by'ibicuruzwa

Izina ry'igicuruzwa	Lemairamin
Irindi zina	2-Propenamide, N-[2-(3,4-dimethoxyphenyl)ethyl]-3-phenyl-, (2E)-; Lemairamin (WGX-50)
Nimero ya CAS	29946-61-0
Ifishi y'ingirabuzimafatizo	C19H21NO3
Uburemere bwa molekile	311.37
Ubwiza	98.0%
Isura	Ifu y'umweru kuva kuri umweru kugeza kuri umweru
Porogaramu	Inyongeramusaruro ku biribwa

Intangiriro y'ibicuruzwa

Lemairamin cyangwa Wgx50 ni ikintu karemano gikomoka kuri chili pepper cyagaragaje umusaruro mwiza mu gukumira indwara ya Alzheimer. Ubushakashatsi bwagaragaje ko gishobora gukumira apoptosis y’imitsi iterwa na Aβ, kugabanya uburozi bwa calcium mu mitsi, no kugabanya kwirundanya kwa Aβ oligomers mu bwonko. Byongeye kandi, wgx50 byagaragaye ko yongera ubushobozi bwo gutekereza mu mbeba. Ubushakashatsi bwerekana ko wgx50 ifite ubushobozi bwo gukumira poroteyine na poroteyine hagati ya molekile za amyloid. Muri rusange, wgx50 ifite ubushobozi bwo gukumira indwara ya Alzheimer kandi ishobora gutanga inzira nshya zo guteza imbere imiti yibasira Aβ oligomers. Byongeye kandi, WGX-50 igaragaza imbaraga zikomeye zo kurwanya ububyimbirwe, bituma iba umuti mwiza wo kuvura indwara ziterwa n’ububyimbirwe. WGX-50 byagaragaye ko igira ingaruka zikomeye ku ruhu, nko kugabanya iminkanyari no kunoza uburyo uruhu rukomera. Uretse ibintu karemano biva mu kimera cya Zanthoxylum bungeanum, ubu hari ibindi bintu by’ubukorano bikoreshwa mu buryo butandukanye kandi bikwiriye ku isoko.

Ikiranga

(1) Ubuziranenge bwinshi: Lemairamin ishobora kubona ibintu bifite ubuziranenge bwinshi binyuze mu gukurura no gutunganya ibintu mu buryo bw’umwimerere. Ubuziranenge bwinshi busobanura ko binyabuzima biboneka neza kandi ingaruka mbi zikaba nke.

(2) Umutekano: Umutekano mwinshi, ingaruka mbi nke, nta ngaruka mbi zigaragara nubwo ikoreshwa igihe kirekire.

(3) Gutuza: Lemairamin ifite ubutuza bwiza kandi ishobora gukomeza imikorere yayo n'ingaruka zayo mu bidukikije bitandukanye no mu buryo butandukanye bwo kubika.

(4) Byoroshye kwinjiza: Lemairamin ishobora kwinjiza vuba umubiri w'umuntu ikagera ku ngingo n'ingingo zitandukanye.

Porogaramu

Lemairamin ni ikintu cya amide gikurwa mu gishishwa cy'igiti cya Zanthoxylum bungeanum. Kuri ubu gikoreshwa nk'inyongera mu mirire, kinakora nk'umusemburo wa alpha7 nicotinic acetylcholine receptor (α7nAChR), igabanya ubukana bw'ubwonko mu ndwara ya Alzheimer, kandi ikaba ikora mu buryo bwa sintetiki. Wgx50 yagaragaje ibisubizo bishimishije mu bushakashatsi bwakozwe mbere y'ibizamini, harimo gukumira apoptosis y'ubwonko iterwa na Aβ, kugabanya uburozi bwa kalisiyumu mu bwonko, kugabanya kwirundanya kwa Aβ oligomers mu bwonko, no kunoza imikorere y'ubwenge mu mbeba.