CMS121 ikora ifu Nomero ya CAS: 1353224-53-9 Isuku ya 98.0% ku bikoresho by'inyongera

4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol ni ikintu cyitwa CMS121. Imiterere y’icyo kintu igaragaza ko gishobora kugira imiterere yihariye n’ikoreshwa rishoboka. Kugira ngo wumve akamaro kacyo, bifasha kumenya amatsinda y’imikorere ahari no gusesengura ingaruka zishobora kubaho. Kuba hari impeta ya quinoline bigaragaza ko icyo kintu gishobora kuba gifite imikorere mu buryo bw’ibinyabuzima. Molekile zikomoka kuri quinoline zizwiho imiterere yazo itandukanye ya biyoloji, harimo n’ibikorwa byo kurwanya bagiteri n’ububyimbirwe. Gufata itsinda rya cyclopentyloxy bishobora kugira uruhare mu gushonga kw’icyo kintu cyangwa kongera imikorere yacyo ya biyoloji binyuze mu ngaruka za steric. Mu bushakashatsi bwakorewe ku turemangingo twa HT22, CMS-121 yagaragaje ingaruka zikomeye zo kurinda ubwonko, ikarinda neza izi selile kwangirika kw’amaraso no kwangirika kwa oxidative. Byongeye kandi, CMS-121 ifite imiterere ikomeye yo kurwanya ububyimbirwe, igaragaza ubushobozi bwayo bwo guhindura uburyo bwo kurwanya ububyimbirwe. Mu kubikora, CMS-121 ifite ubushobozi bwo kugabanya ububyimbirwe mu ngingo n’ingingo zitandukanye. CMS-121 ifite imikorere ikomeye mu by'imiti nk'ibuza acetyl-CoA carboxylase 1 (ACC1). Ingaruka zayo zikomeye ku kubuza ACC1 zituma iba ikintu cyiza.