Ifu ikorwa na Oleoylethanolamide (OEA) No. ya CAS: 111-58-0 98%, 85% ubuziranenge bw'ibicuruzwa by'inyongera
Ibipimo by'ibicuruzwa
| Izina ry'igicuruzwa | Oleoyl ethanolamide |
| Irindi zina | N-oleoyl ethanolamine; N-(2-hydroxyethyl)-,(Z)-9-Octadecenamide |
| Nimero ya CAS | 111-58-0 |
| Ifishi y'ingirabuzimafatizo | C20H39NO2 |
| Uburemere bwa molekile | 325.53 |
| Ubwiza | 98.0% ，85.0% |
| Isura | Ifu nziza y'umweru wa kristu |
| Gupakira | 1kg/umufuka, 25kg/ingoma |
| Porogaramu | Kugabanya ububabare, kurwanya ububyimbirwe |
Intangiriro y'ibicuruzwa
Oleoylethanolamide ni imvange ya kabiri ya amide igizwe na aside oleic lipophilic na ethanolamine ikunda gukamura. Oleoylethanolamide nayo ni molecule y’ibinure isanzwe mu zindi nyamaswa n’ibimera. Iboneka cyane mu nyamaswa n’ibimera nka kakao, soya, n’imbuto z’ibimera, ariko ingano yayo iba nke cyane. Iyo ibidukikije byo hanze bihindutse cyangwa ibiryo bishyushye, ni bwo ingirabuzimafatizo z’umubiri zizakorwa. Icyo gihe ni bwo hazabaho byinshi muri ibi bintu.
Mu bushyuhe bw'icyumba, Oleoylethanolamide ni ikintu cy'umweru gifite ubushyuhe bugera kuri dogere selisiyusi 50. Irashongesha byoroshye mu bintu birimo alcool nka methanol na ethanol, irashongesha byoroshye mu bintu bitari polar nka n-hexane na ether, kandi ntishongesha mu mazi. OEA ni molekile isanzwe ikoreshwa nk'umusemburo n'isabune mu nganda z'imiti. Ariko, ubushakashatsi bwagaragaje ko OEA ishobora gukora nk'umusemburo w'ibimenyetso bya lipid mu gice cy'umutima n'ubwonko kandi ikagaragaza ibikorwa byinshi by'ibinyabuzima mu mubiri, birimo: kugenzura ubushake bwo kurya, kunoza imikorere ya lipide, kongera kwibuka no kumenya n'indi mirimo. Muri byo, imikorere ya Oleoylethanolamide yo kugenzura ubushake bwo kurya no kunoza imikorere ya lipide ni yo yibanzweho cyane.
Oleoylethanolamide ishobora kugenzura uburyo ifata ibiryo n'ingufu binyuze mu gukora receptor-α ikora peroxisome proliferator. Byongeye kandi, Oleoylethanolamide igaragaza ibindi bikorwa bifitanye isano n'ubuzima, harimo guhindura imikorere y'ihindura mu nzira y'ibimenyetso ya lysosomal-to-nuclear ijyanye no kugenzura ubuzima burambye no kurinda imitsi igenzura imyitwarire yo kwiheba. Ubushakashatsi kandi bwerekana ko Oleoylethanolamide ishobora kugira ingaruka zo kurinda ubwonko. Mu nyamaswa, byagaragaye ko igabanya kwangirika guturuka ku guhagarara kw'imitsi no gukomeretsa ubwonko. Ingaruka zo kugenzura za Oleoylethanolamide ziterwa no kwihuza na PPARα, igabanuka hamwe na retinoid X receptor (RXR) kandi ikayikoresha nk'ikintu gikomeye cya transcription factor kigira uruhare mu guhuza ingufu za homeostasis, metabolism ya lipide, autophagy, no kubyimba.
Ikiranga
(1) Ubuziranenge bwinshi: OEA ishobora kubona ibicuruzwa bifite ubuziranenge bwinshi binyuze mu gutunganya umusaruro. Ubuziranenge bwinshi busobanura ko binyabuzima biboneka neza kandi ingaruka mbi zikaba nke.
(2) Umutekano: Byagaragaye ko OEA itekanye ku mubiri w'umuntu.
(3) Gutuza: OEA ifite umutekano mwiza kandi ishobora gukomeza imikorere yayo n'ingaruka zayo mu bidukikije bitandukanye no mu buryo butandukanye bwo kubika.
(4) Byoroshye kwinjiza: OEA ishobora kwinjiza vuba umubiri w'umuntu igakwirakwizwa mu ngingo n'ingingo zitandukanye.
Porogaramu
Oleoylethanolamide ni lipide karemano ya ethanolamide ikoreshwa mu igenamigambi ry'imirire no kugenzura ibiro by'umubiri mu bwoko butandukanye bw'inyamaswa zifite uruhu rw'umugongo. Ni metabolite ya aside oleic ikorwa mu mara mato y'umuntu. Oleylethanolamide (OEA) ni molekile igenga imikorere y'amavuta n'ingufu. Ifata kuri PPAR Alpha receptors kandi igafasha kugenzura ibintu bine: inzara, ibinure mu mubiri, cholesterol n'uburemere. PPAR Alpha ihagarariye alpha ya receptor ikora ya peroxide proliferator, naho lipide oleoylethanolamide (OEA) ifite imiterere itandukanye ya homeostatic, harimo kurwanya ububyimbirwe, guhindura uburyo ubudahangarwa bw'umubiri bukora, n'ingaruka za antioxydants.
