SLU-PP-332 Nomero ya CAS: 303760-60-3
Ibipimo by'ibicuruzwa
| Izina ry'igicuruzwa | SLU-PP-332 |
| Irindi zina | SLU-PP-332； (E)-4-Hydroxy-N′(Naphthalene-2-Ylmethylene)Benzohydrazide；4-Aside Hydroxybenzoic 2-(2-naphthalenylmethylene)hydrazide； |
| Nimero ya CAS | 303760-60-3 |
| Ifishi y'ingirabuzimafatizo | C18H14N2O2 |
| Uburemere bwa molekile | 290.32 |
| Ubwiza | 98% |
| Isura | Ifu y'umweru cyangwa iy'umweru |
| Gupakira | 1kg/umufuka, 25kg/umufuka |
| Porogaramu | Inyongeramusaruro ku biribwa |
Intangiriro y'ibicuruzwa
SLU-PP-332 ni igikoresho gishya cya molekile gikora nk'agace ka perifollicle estrogen receptor (ERR) agonist, kigamije cyane cyane ERRα, ERRβ, na ERRγ, gifite ingaruka zikomeye ku gukora kuri ERRα (EC₅₀=98 nM). Iki gice gikoresha inzira y'ibimenyetso bya ERR bigana uburyo bwo kugenzura imikorere y'imyitozo ngororamubiri, bityo bigahindura imikorere y'ingufu, imikorere ya mitochondrial, no kwihangana kw'imitsi.
Ikiranga
(1) Uburyo bw'imikorere: gukora ERRα/β/γ, kongera imiterere y'uturemangingo dufitanye isano na aside fatty oxidation (FAO) n'ubuhumekero bwa mitochondrial, guteza imbere gusenyuka kw'ibinure kugira ngo bitange ingufu, kugabanya ubwiyongere bw'ibinure, kongera imikorere ya mitochondrial y'imitsi y'amagufwa, kunoza ubushobozi bwa oxidation no kwihangana, kimwe n'ingaruka z'imyitozo ngororamubiri.
(2) Igikorwa cy’umubiri: a) Ingaruka z’ingero z’inyamaswa: Imbeba zibyibushye cyane: nyuma y’iminsi 28 zifata imiti, ibiro by’umubiri byagabanutseho 12%, kandi ibinure by’umwijima, cholesterol, na triglycerides byaragabanutse cyane; imbeba zisanzwe: igihe cyo gukora cyariyongereyeho 70%, intera yiyongereyeho 45%, bitagize ingaruka ku byifuzo cyangwa ku kwimuka ku bushake. b) Umutekano: nta ngaruka mbi zikomeye zagaragaye mu bushakashatsi bwakozwe mbere yo kuvura.
(3) Imiterere y'umubiri n'iya shimi: umweru kugeza ku cyera gikomeye, gishonga muri DMSO (75 mg/mL) na ethanol, kidashonga mu mazi; kigomba kubikwa mu mwijima.
Porogaramu
SLU-PP-332 igabanya ibinure kandi igatunganya isukari mu maraso binyuze mu guteza imbere ogisijeni y'ibinure no kunoza ubushobozi bwo kumva insuline; yongera indwara z'umwijima ziterwa n'ibinure bitari inzoga (NAFLD), igabanya ibinure mu mwijima; itanga ubufasha mu mikorere y'umubiri ku bantu badashobora gukora imyitozo ngororamubiri, ikomeza imitsi n'imikorere yayo; igabanya ibinure mu gihe cyo kugabanuka kw'ibinure; kandi ifite amahirwe menshi mu bijyanye no kugabanuka kw'ibinure, kongera imbaraga mu kwihangana no kunoza imikorere y'umubiri.
